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Chemometric analysis of high performance liquid chromatography-diode array detection-electrospray mass spectrometry of 2- and 3-hydroxypyridine

Triply coupled high performance liquid chromatography using diode array detection and positive ion electrospray mass spectrometry of 2- and 3-hydroxypyridine is presented. Considerations of the physical method for coupling the two detectors, the influence of pH on retention times, the cone voltage o...

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Published in:	Analyst (London) 1998-10, Vol.123 (10), p.2021-2033
Main Authors:	DUNKERLEY, S, CROSBY, J, BRERETON, R. G, ZISSIS, K. D, ESCOTT, R. E. A
Format:	Article
Language:	English
Subjects:	Analytical chemistry Antioxidants - analysis Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid Electronic Data Processing Exact sciences and technology Isomerism Other chromatographic methods Pyridines - analysis Sensitivity and Specificity Spectrometry, Mass, Secondary Ion
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description	Triply coupled high performance liquid chromatography using diode array detection and positive ion electrospray mass spectrometry of 2- and 3-hydroxypyridine is presented. Considerations of the physical method for coupling the two detectors, the influence of pH on retention times, the cone voltage of the mass spectrometer and the linear concentration ranges are described. Data from both detectors are aligned and interpolated. The analyte mass spectra are reduced to 20 significant masses. Principal components plots on the raw, normalised and standardised data, derivatives to determine composition 1 regions, deconvolution and procrustes analysis to compare data from both detectors are discussed. Common trends in both mass spectral and diode array chromatograms are interpreted. This paper represents a new approach to common processing of chromatographic data from two detectors.
doi_str_mv	10.1039/a804345k
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subjects	Analytical chemistry Antioxidants - analysis Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid Electronic Data Processing Exact sciences and technology Isomerism Other chromatographic methods Pyridines - analysis Sensitivity and Specificity Spectrometry, Mass, Secondary Ion
title	Chemometric analysis of high performance liquid chromatography-diode array detection-electrospray mass spectrometry of 2- and 3-hydroxypyridine
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