The Discovery and Development of the Triptans, a Major Therapeutic Breakthrough

The drug discovery programs that led to the development of the triptans were determined by the membership of the American Headache Society to be the most important breakthrough in headache medicine in the last 50 years. Dr. Humphrey, who spearheaded the drug discovery, recounts the pioneering work t...

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Bibliographic Details
Published in:Headache 2008-05, Vol.48 (5), p.685-687
Main Author: Humphrey, Patrick P.A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
History, 20th Century
History, 21st Century
Humans
Injuries of the limb. Injuries of the spine
Medical sciences
Migraine Disorders - drug therapy
Migraine Disorders - history
Migraine Disorders - physiopathology
Neurology
Receptors, Serotonin - physiology
Serotonin Receptor Agonists - history
Serotonin Receptor Agonists - therapeutic use
Sumatriptan - history
Sumatriptan - therapeutic use
Traumas. Diseases due to physical agents
Tryptamines - history
Tryptamines - therapeutic use
Vascular diseases and vascular malformations of the nervous system
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Summary:The drug discovery programs that led to the development of the triptans were determined by the membership of the American Headache Society to be the most important breakthrough in headache medicine in the last 50 years. Dr. Humphrey, who spearheaded the drug discovery, recounts the pioneering work that took place and examines its therapeutic impact.
ISSN:0017-8748
1526-4610
DOI:10.1111/j.1526-4610.2008.01097.x