Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats

Abstract Exercise can increase neurogenesis and affect gene expression in the brains of adult rats. Little is known about how exercise intensity affects neurogenesis and associated gene expression in juvenile rats. Here, we show that exercise influenced neurogenesis and mRNA expression of brain deri...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2008-05, Vol.1210, p.48-55
Main Authors: Lou, Shu-jie, Liu, Jin-yan, Chang, Hui, Chen, Pei-jie
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
BDNF
Biological and medical sciences
Brain-Derived Neurotrophic Factor - genetics
BrdU
Bromodeoxyuridine
Cell Count
Cell Differentiation - genetics
Cell Proliferation
Development. Senescence. Regeneration. Transplantation
Exercise
Exercise Test
Flk-1
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - genetics
Hippocampus
Hippocampus - cytology
Hippocampus - growth & development
Hippocampus - metabolism
Juvenile rat
Male
mRNA
Neurology
Neuronal Plasticity - genetics
Neurons - cytology
Neurons - metabolism
NMDAR1
Physical Conditioning, Animal - physiology
Physical Exertion
Rats
Rats, Sprague-Dawley
Real-time PCR
Receptors, N-Methyl-D-Aspartate - genetics
RNA, Messenger - metabolism
Stem Cells - cytology
Stem Cells - metabolism
Up-Regulation - genetics
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor Receptor-2 - genetics
VEGF
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Exercise can increase neurogenesis and affect gene expression in the brains of adult rats. Little is known about how exercise intensity affects neurogenesis and associated gene expression in juvenile rats. Here, we show that exercise influenced neurogenesis and mRNA expression of brain derived neurotrophic factor (BDNF), N -methyl- d -aspartate receptor type 1 (NMDAR1), vascular endothelial growth factor (VEGF) and fetal liver kinase-1 (Flk-1) in the hippocampus of 5 weeks old rats in an intensity-dependent manner. One week of low- or moderate-intensity exercise in a treadmill running task enhanced neurogenesis in the dentate gyrus of hippocampus. The low-, but not the high-, intensity exercise paradigm resulted in significantly increased expression of BDNF, NMDAR1, and Flk-1 mRNA. Gene expression levels in the low-intensity exercise group were greater than the high-intensity group for these four molecules.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2008.02.080