Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection

Although there are more than 90 serotypes of Streptococcus pneumoniae (or pneumococcus), it is not understood why a small number of serotypes account for most invasive infections. To investigate the human innate immune response triggered by different pneumococcal serotypes, monocyte-derived macropha...

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Published in:FEMS immunology and medical microbiology 2008-06, Vol.53 (1), p.136-139
Main Authors: Burgess, Thomas S.T, Hirschfeld, Aaron F, Tyrrell, Gregory J, Bettinger, Julie A, Turvey, Stuart E
Format: Article
Language:English
Subjects:
Adolescent
Bacteriology
Biological and medical sciences
Cell Line
Child
Child, Preschool
Clinical isolates
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Human behavior
Humans
Immune response
Immune system
immunity
Immunity, Innate - immunology
Infant
Innate immunity
Macrophages
Macrophages - immunology
Macrophages - microbiology
Microbiology
Miscellaneous
Monocytes
Pneumococcal Infections - immunology
Pneumococcal Infections - microbiology
pneumococcus
Serotypes
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - pathogenicity
TNF-α
Tumor Necrosis Factor-alpha - immunology
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vaccines
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Turvey, Stuart E
description Although there are more than 90 serotypes of Streptococcus pneumoniae (or pneumococcus), it is not understood why a small number of serotypes account for most invasive infections. To investigate the human innate immune response triggered by different pneumococcal serotypes, monocyte-derived macrophages were exposed to a group of commonly and rarely invasive pneumococcal clinical isolates and tumor necrosis factor (TNF)-α production was measured. Commonly invasive pneumococcal serotypes triggered significantly less TNF-α production than serotypes rarely responsible for invasive infection (P
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identifier ISSN: 0928-8244
ispartof FEMS immunology and medical microbiology, 2008-06, Vol.53 (1), p.136-139
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2049-632X
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source Oxford Journals Online
subjects Adolescent
Bacteriology
Biological and medical sciences
Cell Line
Child
Child, Preschool
Clinical isolates
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Human behavior
Humans
Immune response
Immune system
immunity
Immunity, Innate - immunology
Infant
Innate immunity
Macrophages
Macrophages - immunology
Macrophages - microbiology
Microbiology
Miscellaneous
Monocytes
Pneumococcal Infections - immunology
Pneumococcal Infections - microbiology
pneumococcus
Serotypes
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - pathogenicity
TNF-α
Tumor Necrosis Factor-alpha - immunology
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vaccines
title Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection
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