Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males

OBJECTIVES The physiological effects of oestrogens on bone in men were largely unanticipated until recently, when oestrogen deficiency in males with aromatase deficiency and oestrogen resistance was found to cause osteoporosis and delayed fusion of epiphyses despite sufficient serum testosterone. Th...

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Published in:Clinical endocrinology (Oxford) 1998-12, Vol.49 (6), p.803-809
Main Authors: Ongphiphadhanakul, B., Rajatanavin, R., Chanprasertyothin, S., Piaseu, N., Chailurkit, L.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Analysis of Variance
Biological and medical sciences
Bone Density - physiology
Estradiol - blood
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Polymorphism, Genetic
Receptors, Estrogen - genetics
Skeleton and joints
Testosterone - blood
Tropical medicine
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:OBJECTIVES The physiological effects of oestrogens on bone in men were largely unanticipated until recently, when oestrogen deficiency in males with aromatase deficiency and oestrogen resistance was found to cause osteoporosis and delayed fusion of epiphyses despite sufficient serum testosterone. This raises the possibility that in normal men oestrogens rather than androgens are of physiological importance in bone maturation. In the present study, we examined the association of serum oestradiol (E2) compared to that of free testosterone (FT) with bone mineral density (BMD) in normal men. The effect of oestrogen receptor (ER) gene polymorphism on BMD in men was also addressed. SUBJECTS Eighty‐one Thai men aged 20–79 years. All were healthy and did not take medication which may affect calcium and bone metabolism. BMD was assessed by DEXA. Dietary calcium was assessed by a 3‐day dietary record. Serum E2 and FT concentrations were measured by radioimmunoassay. Polymorphism at intron 1 of the α isoform of ER gene was determined by PCR–RFLP. Small p represents the presence of the restriction site while capital P indicates the absence of the restriction site. RESULTS Serum FT decreased with increasing age (r = −0.58, P 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.1998.00631.x