Pharmacokinetics and pharmacodynamics of meloxicam in piglets

The pharmacokinetics and pharmacodynamics of meloxicam in piglets (16-23 days old) were studied using a stratified parallel group design. One group (n = 13) received 0.4 mg/kg meloxicam intravenously, while the other group (n = 12) received physiological saline solution. A carrageenan-sponge model o...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2008-06, Vol.31 (3), p.246-252
Main Authors: FOSSE, T.K, HAGA, H.A, HORMAZABAL, V, HAUGEJORDEN, G, HORSBERG, T.E, RANHEIM, B
Format: Article
Language:English
Subjects:
adverse effects
analgesia
analgesics
Animals
Animals, Newborn
anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Area Under Curve
bioavailability
biochemical pathways
biomarkers
Dinoprostone - antagonists & inhibitors
dosage
drug evaluation
Female
Half-Life
inflammation
intravenous injection
Male
meloxicam
Metabolic Clearance Rate
nonsteroidal anti-inflammatory agents
pharmacokinetics
physiological response
piglets
prostaglandins
Swine
Thiazines - pharmacokinetics
Thiazines - pharmacology
Thiazoles - pharmacokinetics
Thiazoles - pharmacology
Thromboxane A2 - antagonists & inhibitors
Thromboxane A2 - biosynthesis
thromboxanes
veterinary drugs
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Summary:The pharmacokinetics and pharmacodynamics of meloxicam in piglets (16-23 days old) were studied using a stratified parallel group design. One group (n = 13) received 0.4 mg/kg meloxicam intravenously, while the other group (n = 12) received physiological saline solution. A carrageenan-sponge model of acute inflammation was used to evaluate the effects of meloxicam. The plasma clearance was low (0.061 L/kg/h), the volume of distribution was low (0.19 L/kg) and the elimination half-life was short (2.7 h). At most time points, the mean concentration of meloxicam in plasma exceeded the concentrations in exudate indicating a limited accumulation of the drug at the site of the inflammation. There were significant differences between the groups in the exudate prostaglandin E₂ (PGE₂) concentration, but the inhibition of PGE₂ in the meloxicam group was limited. The inhibition of thromboxane B₂ (TXB₂) production in serum in the meloxicam group was extensive, but of shorter duration than the PGE₂ inhibition in exudate.
ISSN:0140-7783
1365-2885
DOI:10.1111/j.1365-2885.2008.00958.x