Prediction of lymphatic metastasis based on gene expression profile analysis after brachytherapy for early-stage oral tongue carcinoma

Abstract Background and purpose The management of lymphatic metastasis of early-stage oral tongue carcinoma patients is crucial for its prognosis. The purpose of this study was to evaluate the predictive ability of lymphatic metastasis after brachytherapy (BRT) for early-stage tongue carcinoma based...

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Bibliographic Details
Published in:Radiotherapy and oncology 2008-05, Vol.87 (2), p.237-242
Main Authors: Watanabe, Hiroshi, Mogushi, Kaoru, Miura, Masahiko, Yoshimura, Ryo-ichi, Kurabayashi, Tohru, Shibuya, Hitoshi, Tanaka, Hiroshi, Noda, Shuhei, Iwakawa, Mayumi, Imai, Takashi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brachytherapy
Carcinoma - genetics
Carcinoma - pathology
Carcinoma - radiotherapy
Female
Gene expression profile
Gene Expression Profiling
Hematology, Oncology and Palliative Medicine
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Prediction
Predictive Value of Tests
Prognosis
Tongue cancer
Tongue Neoplasms - genetics
Tongue Neoplasms - pathology
Tongue Neoplasms - radiotherapy
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Summary:Abstract Background and purpose The management of lymphatic metastasis of early-stage oral tongue carcinoma patients is crucial for its prognosis. The purpose of this study was to evaluate the predictive ability of lymphatic metastasis after brachytherapy (BRT) for early-stage tongue carcinoma based on gene expression profiling. Patients and methods Pre-therapeutic biopsies from 39 patients with T1 or T2 tongue cancer were analyzed for gene expression signatures using Codelink Uniset Human 20K Bioarray. All patients were treated with low dose-rate BRT for their primary lesions and underwent strict follow-up under a wait-and-see policy for cervical lymphatic metastasis. Candidate genes were selected for predicting lymph-node status in the reference group by the permutation test. Predictive accuracy was further evaluated by the prediction strength (PS) scoring system using an independent validation group. Results We selected a set of 19 genes whose expression differed significantly between classes with or without lymphatic metastasis in the reference group. The lymph-node status in the validation group was predicted by the PS scoring system with an accuracy of 76%. Conclusions Gene expression profiling using 19 genes in primary tumor tissues may allow prediction of lymphatic metastasis after BRT for early-stage oral tongue carcinoma.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2007.12.027