Matrix metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 in premenopausal obese women: relationship to cardiac function

• Published in: International Journal of Obesity 2008-05, Vol.32 (5), p.763-771
• Main Authors: Kosmala, W, Plaksej, R, Przewlocka-Kosmala, M, Kuliczkowska-Plaksej, J, Bednarek-Tupikowska, G, Mazurek, W
• Format: Article
• Language: English
• Subjects: Adult; adults; biochemical mechanisms; Biological and medical sciences; biomarkers; blood plasma; Body Mass Index; Cardiac function; Cardiomyopathies - enzymology; Cardiomyopathies - epidemiology; Cardiomyopathy; Cardiovascular disease; Cardiovascular system; Care and treatment; congestive heart failure; Diabetes; Diagnosis; Down-Regulation; Enzymes; epidemiological studies; Epidemiology; Extracellular matrix; Female; Females; fibrosis; Glucose; Health Promotion and Disease Prevention; Heart diseases; Heart failure; heart ventricle; Homeostasis; Humans; Hypertension; Immunoassay; Inhibitors; Insulin; Insulin resistance; Internal Medicine; Investigative techniques, diagnostic techniques (general aspects); Matrix Metalloproteinase 2 - blood; Matrix Metalloproteinase 9 - blood; Medical examination; Medical sciences; Medicine; Medicine & Public Health; Menstruation; Metabolic Diseases; Metabolism; metalloproteinases; myocardium; Obesity; Obesity - blood; Obesity - physiopathology; obesity-related diseases; original-article; Overweight persons; pathogenesis; pathophysiology; Physiological aspects; Plasma; Premenopause - blood; Public Health; Risk factors; Tissue Inhibitor of Metalloproteinase-1 - blood; Tissue Inhibitor of Metalloproteinase-2 - blood; tissue inhibitors; Ultrasonic investigative techniques; Ventricular Dysfunction, Left - enzymology; Ventricular Dysfunction, Left - etiology; women; Womens health
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0803794

Background: Myocardial fibrosis is one of the mechanisms underlying left ventricular (LV) dysfunction in obese patients and may result from dysregulation of extracellular matrix (ECM) turnover. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) represent a regulatory system playing a crucial role in ECM metabolism. Objectives: We sought to assess plasma levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in obese young women and to evaluate the association between MMP/TIMP system components and LV function in this population. Design: Prospective, cross-sectional study. Setting: University hospital. Patients: Seventy-one women aged 30 kg m- 2 and 30 healthy slim female controls. Main outcome measures: Plasma MMP-2, MMP-9, TIMP-1 and TIMP-2 measurements and echocardiographic studies, including LV strain/strain rate evaluation. Results: We demonstrated increased levels of MMP-9 and TIMP-1 and decreased MMP-2 in the obese population. LV dysfunction shown in patients with obesity was characterized by significantly lower values of strain/strain rate parameters. Plasma MMP-2 correlated positively and TIMP-1 negatively with systolic strain (r=0.39, P