Complications of diabetes in urban Indigenous Australians: The DRUID study

• Published in: Diabetes research and clinical practice 2008-06, Vol.80 (3), p.455-462
• Main Authors: Maple-Brown, Louise, Cunningham, Joan, Dunne, Karin, Whitbread, Cherie, Howard, Diane, Weeramanthri, Tarun, Tatipata, Shaun, Dunbar, Terry, Harper, Colin A, Taylor, Hugh R, Zimmet, Paul, O’Dea, Kerin, Shaw, Jonathan E
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Albuminuria; Cross-Sectional Studies; Diabetes Complications - epidemiology; Diabetes management; Diabetes Mellitus - classification; Endocrinology & Metabolism; Humans; Indigenous Australian; Life Style; Neuropathy; Northern Territory - epidemiology; Obesity - epidemiology; Obesity - prevention & control; Patient Selection; Peripheral vascular disease; Retinopathy
• ISSN: 0168-8227; 1872-8227; 1872-8227
• DOI: 10.1016/j.diabres.2008.01.011

Abstract Aims To accurately assess the management and complications of type 2 diabetes in urban Indigenous Australians and compare the risk of complications with a general Australian population (AusDiab Study). Methods The Darwin Region Urban Indigenous Diabetes (DRUID) Study included 1004 volunteers aged ≥15 years; diabetes status was classifiable for 866. The assessment of diabetic complications and metabolic control was performed in participants with known diabetes (KDM) and diabetes newly diagnosed by the study (NDM) using an interviewer-administered questionnaire and clinical examination. Results Among 172 DRUID participants eligible for complications assessment, 135 were assessed, including 99 KDM (mean age 53 years) and 36 NDM (mean age 47 years). Percentages of KDM participants meeting therapeutic targets were: HbA1c < 7%, 29%; blood pressure < 130/80 mmHg, 45%; total cholesterol < 5.5mmol/L, 65%. Among KDM, 39% had albuminuria, 21% retinopathy, 12% peripheral vascular disease (PVD), 9% neuropathy. Factors independently associated with diabetic complications were: albuminuria–HbA1c, systolic blood pressure; retinopathy–diabetes duration; PVD–age. Compared to AusDiab participants after adjusting for other risk factors, DRUID participants had 2–3-fold increased risk of albuminuria and PVD and a non-significant increased risk of neuropathy, but no increased risk of retinopathy. Conclusions Urban Indigenous Australians with diabetes are relatively young and have poor glycaemic control. Compared to the general Australian population with type 2 diabetes, they have greater adjusted risk of albuminuria and PVD but not retinopathy. Urgent action is required to prevent diabetes at a population level and improve diabetes management in this high-risk population.