Zinc supplementation increases resistance to experimental infection by Trypanosoma cruzi

• Published in: Veterinary parasitology 2008-06, Vol.154 (1), p.32-37
• Main Authors: Brazão, Vânia, Caetano, Leony Cristina, Del Vecchio Filipin, Marina, Paula Alonso Toldo, Miriam, Caetano, Luana Naiara, do Prado, José Clóvis
• Format: Article
• Language: English
• Subjects: animal models; animal pathogens; Animals; B-lymphocytes; cell proliferation; Chagas disease; Concanavalin A - pharmacology; dietary mineral supplements; dietary minerals; disease resistance; immunity; interleukin-12; Interleukin-12 (IL-12); Interleukin-12 - metabolism; intracellular pathogens; macrophages; Male; mortality; natural killer cells; Parasitemia - drug therapy; Rats; Rats, Wistar; resistance mechanisms; Spleen - cytology; Spleen - drug effects; splenocytes; T-lymphocytes; Thymocyte and splenocyte proliferation; thymocytes; Thymus Gland - cytology; Thymus Gland - drug effects; Time Factors; Trypanosoma cruzi; Trypanosomiasis - prevention & control; Zinc; Zinc - pharmacology
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/j.vetpar.2008.02.015

It is well recognized that zinc is an essential trace element for all organisms, influencing growth and affecting the development and integrity of the immune system. It is also well known that the protective response against Trypanosoma cruzi depends on both innate and acquired immunity and for the control of the parasite load and host survival, the participation of special cells such natural killer (NK), T and B lymphocytes and macrophages are required. So the aims of this study were to evaluate the effects of zinc supplementation on the host's immune response infected with T. cruzi. Our data point in the direction that zinc supplementation triggered enhanced thymocyte and splenocyte proliferation as compared to unsupplied group of animals. It is also important to emphasize that interleukin-12 (IL-12) participates in the resistance to several intracellular pathogens including T. cruzi. Our findings demonstrate an enhanced production of IL-12 during the acute phase of infection in zinc-supplied groups. So we conclude that zinc supplementation leads to an effective host's immune response by up-modulating the host's immune response, thus contributing in the reduction of blood parasites and the harmful pathogenic effects of the experimental Chagas’ disease.