Early effects of surgery on zinc and metallothionein levels in female rats

Time-response effects of experimental surgery on zinc (Zn) and metallothionein (MT) homeostasis were investigated in female rats up to 24 h. Hepatic Zn content increased at 20 and 24 h postsurgery, whereas serum Zn levels decreased. Hepatic MT increased significantly by 9 h postsurgery and peaked at...

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Bibliographic Details
Published in:Biological trace element research 1999-11, Vol.70 (2), p.173-182
Main Authors: Brambila, E, Muñoz-Sánchez, J L, Albores, A, Waalkes, M
Format: Article
Language:English
Subjects:
Animals
Female
Females
Homeostasis
Inflammation
Inflammation - etiology
Inflammation - metabolism
Isoforms
Laparotomy - adverse effects
Liver
Liver - metabolism
Male
Metallothionein
Metallothionein - analysis
Postoperative Complications - metabolism
Protein Isoforms
Rats
Rats, Wistar
Rodents
Serum
Surgery
Surgical operations
Zinc
Zinc - analysis
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Summary:Time-response effects of experimental surgery on zinc (Zn) and metallothionein (MT) homeostasis were investigated in female rats up to 24 h. Hepatic Zn content increased at 20 and 24 h postsurgery, whereas serum Zn levels decreased. Hepatic MT increased significantly by 9 h postsurgery and peaked at up to twofold of control at 12 h after surgery. Following the peak at 12 h, hepatic MT content decreased with time but did not reach control levels at the end of this study. When MT isoforms were evaluated, MT-II levels were elevated to the highest extent by 12 h after surgery, whereas MT-I levels started to decrease after 3 h postsurgery but then increased by 20 h. The early increases in MT content are probably mediated by nonmetallic mediators released during the postsurgical inflammatory process, favoring the plasma/tissue mobilization of Zn. This process might be part of the overall mechanisms occurring in the inflammation.
ISSN:0163-4984
1559-0720
DOI:10.1007/BF02783858