Manic-depressive psychosis as prevalent manifestation of multiple sclerosis

Manic-depressive psychosis (MDP) and multiple sclerosis (MS) coexistence is unusual but well-proven. We report two cases observed in two women aged 30 and 31, who were followed up for neurological episodes associated with concomitant or deferred manic or depressive fits. Brain magnetic resonance ima...

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Bibliographic Details
Published in:Revue neurologique 2008-05, Vol.164 (5), p.472-476
Main Authors: El Moutawakil, B, Sibai, M, Bourezgui, M, Boulaajaj, F Z, Rafai, M A, Gam, I, Slassi, I
Format: Article
Language:fre
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Bipolar Disorder - drug therapy
Bipolar Disorder - etiology
Brain - pathology
Diabetes Mellitus, Type 1 - complications
Female
Humans
Magnetic Resonance Imaging
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
Multiple Sclerosis - pathology
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Summary:Manic-depressive psychosis (MDP) and multiple sclerosis (MS) coexistence is unusual but well-proven. We report two cases observed in two women aged 30 and 31, who were followed up for neurological episodes associated with concomitant or deferred manic or depressive fits. Brain magnetic resonance imaging revealed multiple zones of high intensity signals in the white matter. Biological balance was normal. The diagnosis of multiple sclerosis (MS) was established. Given to treat acute episodes, high-dose corticosteroids enabled regression of the psychological fits. Similarly, long-term treatment in one patient enabled significant regression of fits, which became less frequent and less severe. The MDP-MS association may be due to local MS-related brain damage or to common genetic susceptibility. The positive effect of corticosteroids against psychological fits is another finding favouring an organic cause of these disorders.
ISSN:0035-3787
DOI:10.1016/j.neurol.2008.02.041