gpDB: a database of GPCRs, G-proteins, effectors and their interactions

• Published in: Bioinformatics 2008-06, Vol.24 (12), p.1471-1472
• Main Authors: Theodoropoulou, Margarita C., Bagos, Pantelis G., Spyropoulos, Ioannis C., Hamodrakas, Stavros J.
• Format: Article
• Language: English
• Subjects: Algorithms; Amino Acid Motifs; Amino Acid Sequence; Biological and medical sciences; Conserved Sequence; Database Management Systems; Databases, Protein; Fundamental and applied biological sciences. Psychology; General aspects; GTP-Binding Proteins - chemistry; Information Storage and Retrieval - methods; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Molecular Sequence Data; Protein Interaction Mapping - methods; Protein Structure, Tertiary; Receptors, G-Protein-Coupled - chemistry; Sequence Alignment - methods; Sequence Analysis, Protein - methods; User-Computer Interface
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btn206

gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database. Availability: http://bioinformatics.biol.uoa.gr/gpDB Contact: [e-mail] Supplementary information: Supplementary data are available at Bioinformatics online.