Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance

The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance. We studied 112 patients with T2DM and...

Full description

Saved in:
Bibliographic Details
Published in:Clinical biochemistry 2008-07, Vol.41 (10), p.812-817
Main Authors: Fujinami, Aya, Ohta, Kiyoe, Obayashi, Hiroshi, Fukui, Michiaki, Hasegawa, Goji, Nakamura, Naoto, Kozai, Hana, Imai, Saeko, Ohta, Mitsuhiro
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance. We studied 112 patients with T2DM and 80 age- and gender-matched control subjects. Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5 ± 5.2 ng/mL vs. 20.0 ± 7.3 ng/mL, P < 0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males ( P < 0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) ( ρ = 0.458, P < 0.05) and HOMA-R ( ρ = 0.444, P < 0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI ( F = 5.294, P < 0.05) in female patients with diabetes. These findings suggest that BDNF may contribute to glucose metabolism.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2008.03.003