Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance
The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance. We studied 112 patients with T2DM and...
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Published in: | Clinical biochemistry 2008-07, Vol.41 (10), p.812-817 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.
We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.
Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5
±
5.2 ng/mL
vs. 20.0
±
7.3 ng/mL,
P
<
0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (
P
<
0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (
ρ
=
0.458,
P
<
0.05) and HOMA-R (
ρ
=
0.444,
P
<
0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (
F
=
5.294,
P
<
0.05) in female patients with diabetes.
These findings suggest that BDNF may contribute to glucose metabolism. |
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ISSN: | 0009-9120 1873-2933 |
DOI: | 10.1016/j.clinbiochem.2008.03.003 |