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Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance
The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance. We studied 112 patients with T2DM and...
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| Published in: | Clinical biochemistry 2008-07, Vol.41 (10), p.812-817 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c406t-5ffbee5805727c6c945680cb299153a2d51e1d297aaa3998b59ead27aaedc4e63 |
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| cites | cdi_FETCH-LOGICAL-c406t-5ffbee5805727c6c945680cb299153a2d51e1d297aaa3998b59ead27aaedc4e63 |
| container_end_page | 817 |
| container_issue | 10 |
| container_start_page | 812 |
| container_title | Clinical biochemistry |
| container_volume | 41 |
| creator | Fujinami, Aya Ohta, Kiyoe Obayashi, Hiroshi Fukui, Michiaki Hasegawa, Goji Nakamura, Naoto Kozai, Hana Imai, Saeko Ohta, Mitsuhiro |
| description | The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.
We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.
Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5
±
5.2 ng/mL
vs. 20.0
±
7.3 ng/mL,
P
<
0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (
P
<
0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (
ρ
=
0.458,
P
<
0.05) and HOMA-R (
ρ
=
0.444,
P
<
0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (
F
=
5.294,
P
<
0.05) in female patients with diabetes.
These findings suggest that BDNF may contribute to glucose metabolism. |
| doi_str_mv | 10.1016/j.clinbiochem.2008.03.003 |
| format | article |
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We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.
Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5
±
5.2 ng/mL
vs. 20.0
±
7.3 ng/mL,
P
<
0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (
P
<
0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (
ρ
=
0.458,
P
<
0.05) and HOMA-R (
ρ
=
0.444,
P
<
0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (
F
=
5.294,
P
<
0.05) in female patients with diabetes.
These findings suggest that BDNF may contribute to glucose metabolism.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2008.03.003</identifier><identifier>PMID: 18402781</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adiponectin ; Adiponectin - blood ; Aged ; Albuminuria ; Blood Glucose - metabolism ; Blood Pressure ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Creatinine - urine ; Diabetes Mellitus, Type 2 - blood ; Female ; Humans ; Insulin ; Insulin - blood ; Insulin Resistance - physiology ; Leptin ; Leptin - blood ; Male ; Middle Aged ; Patient Selection ; Reference Values ; Type 2 diabetes</subject><ispartof>Clinical biochemistry, 2008-07, Vol.41 (10), p.812-817</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-5ffbee5805727c6c945680cb299153a2d51e1d297aaa3998b59ead27aaedc4e63</citedby><cites>FETCH-LOGICAL-c406t-5ffbee5805727c6c945680cb299153a2d51e1d297aaa3998b59ead27aaedc4e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18402781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujinami, Aya</creatorcontrib><creatorcontrib>Ohta, Kiyoe</creatorcontrib><creatorcontrib>Obayashi, Hiroshi</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><creatorcontrib>Hasegawa, Goji</creatorcontrib><creatorcontrib>Nakamura, Naoto</creatorcontrib><creatorcontrib>Kozai, Hana</creatorcontrib><creatorcontrib>Imai, Saeko</creatorcontrib><creatorcontrib>Ohta, Mitsuhiro</creatorcontrib><title>Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.
We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.
Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5
±
5.2 ng/mL
vs. 20.0
±
7.3 ng/mL,
P
<
0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (
P
<
0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (
ρ
=
0.458,
P
<
0.05) and HOMA-R (
ρ
=
0.444,
P
<
0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (
F
=
5.294,
P
<
0.05) in female patients with diabetes.
These findings suggest that BDNF may contribute to glucose metabolism.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Aged</subject><subject>Albuminuria</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Creatinine - urine</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Selection</subject><subject>Reference Values</subject><subject>Type 2 diabetes</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkcuKFDEUhoMoTs_oK0jcuKsyl7rFnTSjDgwIXtYhlZyy01YlZU5qZF7FpzVDN-hOV-HAdy5_PkJeclZzxrvXx9rOPow-2gMstWBsqJmsGZOPyI4PvayEkvIx2THGVKW4YBfkEvFYStEM3VNywYeGiX7gO_LrM6RtoWMyPlQOkr8DRwNsKeYU14O3dDI2x0R9oKvJHkJG-tPnA833K1BBnTcjZEC6wDz7vOEb-gnmQsaAB7_SHOm3ebMRoRDZjHH2uFATHC33LyZ9h4Q0TmU-biUUTYAeswkWnpEnk5kRnp_fK_L13fWX_Yfq9uP7m_3b28o2rMtVO00jQDuwthe97axq2m5gdhRK8VYa4VoO3AnVG2OkUsPYKjBOlBKcbaCTV-TVae6a4o8NMOvFoy1pTIC4oe6U4FI2_T9BwYZygxIFVCfQpoiYYNJr8iXrveZMPxjUR_2XQf1gUDOpi8HS--K8ZBsXcH86z8oKsD8BUP7kzkPSaIsWC84nsFm76P9jzW_dXLcv</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Fujinami, Aya</creator><creator>Ohta, Kiyoe</creator><creator>Obayashi, Hiroshi</creator><creator>Fukui, Michiaki</creator><creator>Hasegawa, Goji</creator><creator>Nakamura, Naoto</creator><creator>Kozai, Hana</creator><creator>Imai, Saeko</creator><creator>Ohta, Mitsuhiro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance</title><author>Fujinami, Aya ; Ohta, Kiyoe ; Obayashi, Hiroshi ; Fukui, Michiaki ; Hasegawa, Goji ; Nakamura, Naoto ; Kozai, Hana ; Imai, Saeko ; Ohta, Mitsuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-5ffbee5805727c6c945680cb299153a2d51e1d297aaa3998b59ead27aaedc4e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Aged</topic><topic>Albuminuria</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Creatinine - urine</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Selection</topic><topic>Reference Values</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujinami, Aya</creatorcontrib><creatorcontrib>Ohta, Kiyoe</creatorcontrib><creatorcontrib>Obayashi, Hiroshi</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><creatorcontrib>Hasegawa, Goji</creatorcontrib><creatorcontrib>Nakamura, Naoto</creatorcontrib><creatorcontrib>Kozai, Hana</creatorcontrib><creatorcontrib>Imai, Saeko</creatorcontrib><creatorcontrib>Ohta, Mitsuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujinami, Aya</au><au>Ohta, Kiyoe</au><au>Obayashi, Hiroshi</au><au>Fukui, Michiaki</au><au>Hasegawa, Goji</au><au>Nakamura, Naoto</au><au>Kozai, Hana</au><au>Imai, Saeko</au><au>Ohta, Mitsuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>41</volume><issue>10</issue><spage>812</spage><epage>817</epage><pages>812-817</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.
We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.
Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5
±
5.2 ng/mL
vs. 20.0
±
7.3 ng/mL,
P
<
0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (
P
<
0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (
ρ
=
0.458,
P
<
0.05) and HOMA-R (
ρ
=
0.444,
P
<
0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (
F
=
5.294,
P
<
0.05) in female patients with diabetes.
These findings suggest that BDNF may contribute to glucose metabolism.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18402781</pmid><doi>10.1016/j.clinbiochem.2008.03.003</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9120 |
| ispartof | Clinical biochemistry, 2008-07, Vol.41 (10), p.812-817 |
| issn | 0009-9120 1873-2933 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69213347 |
| source | ScienceDirect Journals |
| subjects | Adiponectin Adiponectin - blood Aged Albuminuria Blood Glucose - metabolism Blood Pressure Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Creatinine - urine Diabetes Mellitus, Type 2 - blood Female Humans Insulin Insulin - blood Insulin Resistance - physiology Leptin Leptin - blood Male Middle Aged Patient Selection Reference Values Type 2 diabetes |
| title | Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance |
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