Endothelial cell functions. Relationship to atherogenesis

The vascular endothelium plays a critical role in the preservation of normal vessel wall structure and function. In particular, endothelial cells control vascular permeability, vessel tone, coagulation, fibrinolysis, and inflammatory responses. These functions are accomplished by production of a var...

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Bibliographic Details
Published in:Basic research in cardiology 1999-10, Vol.94 (5), p.295-314
Main Authors: Toborek, M, Kaiser, S
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - physiopathology
Blood Vessels - physiology
Blood Vessels - physiopathology
Capillary Permeability
Endothelium, Vascular - physiology
Endothelium, Vascular - physiopathology
Humans
Models, Cardiovascular
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Summary:The vascular endothelium plays a critical role in the preservation of normal vessel wall structure and function. In particular, endothelial cells control vascular permeability, vessel tone, coagulation, fibrinolysis, and inflammatory responses. These functions are accomplished by production of a variety of biologically active substances. However, endothelial cell-mediated reactions may also lead to the development of pathological stages within the vessel wall. The current review is focused on endothelial cell metabolism in relationship to the development of atherosclerosis.
ISSN:0300-8428
1435-1803
DOI:10.1007/s003950050156