Prevalence of TT virus in patients with fulminant hepatic failure in Japan

A novel virus (TT virus) was isolated from patients with posttransfusion hepatitis of unknown etiology. We studied the prevalence of TT virus in 26 patients with fulminant hepatic failure without risk factors, including blood transfusion, and also examined 106 healthy blood donors as controls. We as...

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Bibliographic Details
Published in:Journal of gastroenterology 1999-10, Vol.34 (5), p.589-593
Main Authors: Tanaka, M, Nishiguchi, S, Tanaka, T, Enomoto, M, Takeda, T, Shiomi, S, Kuroki, T, Otani, S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
DNA Virus Infections - blood
DNA Virus Infections - complications
DNA Virus Infections - diagnosis
DNA Virus Infections - epidemiology
DNA Viruses - classification
DNA Viruses - isolation & purification
Female
Hepatic Encephalopathy - blood
Hepatic Encephalopathy - virology
Hepatitis Antibodies - blood
Humans
Japan - epidemiology
Male
Middle Aged
Prevalence
Risk Factors
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Summary:A novel virus (TT virus) was isolated from patients with posttransfusion hepatitis of unknown etiology. We studied the prevalence of TT virus in 26 patients with fulminant hepatic failure without risk factors, including blood transfusion, and also examined 106 healthy blood donors as controls. We assayed serum TT virus DNA by seminested polymerase chain reactions and also examined the genotypes of this virus. Serum was obtained at admission from patients with fulminant hepatic failure. Serum samples at admission from seven (27%) of the 26 patients were positive for TT virus DNA. There were no differences in clinical findings, duration from onset to coma, or results of laboratory tests in patients with and without TT virus DNA. However, all 7 patients with TT virus died, whereas 9 of the 19 patients without TT virus died. The outcome for patients with fulminant hepatic failure and TT virus was significantly worse than for patients without the virus (P = 0.0227). TT virus was also detected in 29 (27%) of the 106 healthy blood donors. The genotype of the TT virus was mainly 1a in both groups. There were no differences in the rate of positivity and the genotypes of TT virus between patients with fulminant hepatic failure and healthy blood donors. TT virus infection may not cause severe hepatitis, such as fulminant hepatic failure, but it may indicate a poor outcome in such patients.
ISSN:0944-1174
DOI:10.1007/s005350050377