Role of Axonal Transport in Neurodegenerative Diseases

Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pat...

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Bibliographic Details
Published in:Annual review of neuroscience 2008-01, Vol.31 (1), p.151-173
Main Authors: DE VOS, Kurt J, GRIERSON, Andrew J, ACKERLEY, Steven, MILLER, Christopher C. J
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Animals
Axonal Transport - genetics
Axons - metabolism
Axons - pathology
Biological and medical sciences
Central Nervous System - metabolism
Central Nervous System - pathology
Central Nervous System - physiopathology
Charcot-Marie-Tooth Disease - genetics
Charcot-Marie-Tooth Disease - metabolism
Charcot-Marie-Tooth Disease - physiopathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Humans
Huntington Disease - genetics
Huntington Disease - metabolism
Huntington Disease - physiopathology
Medical sciences
Motor Neuron Disease - genetics
Motor Neuron Disease - metabolism
Motor Neuron Disease - physiopathology
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - physiopathology
Neurology
Organic mental disorders. Neuropsychology
Parkinson Disease - genetics
Parkinson Disease - metabolism
Parkinson Disease - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.
ISSN:0147-006X
1545-4126
DOI:10.1146/annurev.neuro.31.061307.090711