Low serum C3, leukopenia, and thrombocytopenia : unusual features of Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually...

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Bibliographic Details
Published in:European journal of pediatrics 1999-11, Vol.158 (11), p.906-909
Main Authors: KRAUSE, I, GARTY, B. Z, DAVIDOVITS, M, CLEPER, R, TAMARY, H, ROSENMANN, E, EISENSTEIN, B
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy, Needle
Blood and lymphatic vessels
Cardiology. Vascular system
Child
Complement C3c - analysis
Disease Progression
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Glomerulonephritis, Membranoproliferative - etiology
Glomerulonephritis, Membranoproliferative - pathology
Glomerulonephritis, Membranoproliferative - therapy
Humans
Kidney Failure, Chronic - surgery
Kidney Failure, Chronic - therapy
Kidney Transplantation
Leukopenia - etiology
Male
Medical sciences
Purpura, Schoenlein-Henoch - complications
Purpura, Schoenlein-Henoch - diagnosis
Renal Dialysis
Thrombocytopenia - etiology
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Summary:Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually normal. We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP.
ISSN:0340-6199
1432-1076
DOI:10.1007/s004310051239