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Low serum C3, leukopenia, and thrombocytopenia : unusual features of Henoch-Schonlein purpura

Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually...

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Published in:	European journal of pediatrics 1999-11, Vol.158 (11), p.906-909
Main Authors:	KRAUSE, I, GARTY, B. Z, DAVIDOVITS, M, CLEPER, R, TAMARY, H, ROSENMANN, E, EISENSTEIN, B
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Biopsy, Needle Blood and lymphatic vessels Cardiology. Vascular system Child Complement C3c - analysis Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Glomerulonephritis, Membranoproliferative - etiology Glomerulonephritis, Membranoproliferative - pathology Glomerulonephritis, Membranoproliferative - therapy Humans Kidney Failure, Chronic - surgery Kidney Failure, Chronic - therapy Kidney Transplantation Leukopenia - etiology Male Medical sciences Purpura, Schoenlein-Henoch - complications Purpura, Schoenlein-Henoch - diagnosis Renal Dialysis Thrombocytopenia - etiology
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container_end_page	909
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creator	KRAUSE, I GARTY, B. Z DAVIDOVITS, M CLEPER, R TAMARY, H ROSENMANN, E EISENSTEIN, B
description	Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually normal. We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP.
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subjects	Biological and medical sciences Biopsy, Needle Blood and lymphatic vessels Cardiology. Vascular system Child Complement C3c - analysis Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Glomerulonephritis, Membranoproliferative - etiology Glomerulonephritis, Membranoproliferative - pathology Glomerulonephritis, Membranoproliferative - therapy Humans Kidney Failure, Chronic - surgery Kidney Failure, Chronic - therapy Kidney Transplantation Leukopenia - etiology Male Medical sciences Purpura, Schoenlein-Henoch - complications Purpura, Schoenlein-Henoch - diagnosis Renal Dialysis Thrombocytopenia - etiology
title	Low serum C3, leukopenia, and thrombocytopenia : unusual features of Henoch-Schonlein purpura
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