Loading…

Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis

Objectives. To assess if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be associated with an increased risk of calcinosis in children with juvenile dermatomyositis (JDM). Methods. The frequency of calcinosis was deri...

Full description

Saved in:
Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2008-07, Vol.47 (7), p.1031-1037
Main Authors: Marhaug, G., Shah, V., Shroff, R., Varsani, H., Wedderburn, L. R., Pilkington, C. A., Brogan, P. A.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3
cites cdi_FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3
container_end_page 1037
container_issue 7
container_start_page 1031
container_title Rheumatology (Oxford, England)
container_volume 47
creator Marhaug, G.
Shah, V.
Shroff, R.
Varsani, H.
Wedderburn, L. R.
Pilkington, C. A.
Brogan, P. A.
description Objectives. To assess if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be associated with an increased risk of calcinosis in children with juvenile dermatomyositis (JDM). Methods. The frequency of calcinosis was derived from a national UK database of 212 cases of JDM. Serum fetuin-A and plasma osteopontin levels were determined using ELISA in 15 JDM patients with calcinosis and 15 JDM patients without calcinosis. Healthy controls were 19 age-matched children, 24 adolescents and 13 adults. Sixteen patients with juvenile idiopathic arthritis (JIA) were additional paediatric disease controls. Results. Of the 212 JDM cases 10% had calcinosis. Calcinosis patients had younger age of disease onset than those without calcinosis (mean age of 5.3 yrs vs 7.1 yrs, respectively, P = 0.016). No significant difference in fetuin-A or osteopontin could be detected between the two JDM groups. Fetuin-A levels in all groups of children and the adolescent group were much lower than described previously in adults, and there was a significant positive correlation between age and fetuin-A level, and also between osteopontin levels in plasma and serum fetuin-A. Conclusions. Children who develop JDM at an younger age may have increased risk of developing calcinosis. Physiologically low levels of fetuin-A in young children combined with an additional negative acute-phase effect on fetuin-A due to chronic inflammation could explain in part the propensity to develop ectopic calcification observed in JDM patients, and why calcinosis is less frequent in adults with dermatomyositis.
doi_str_mv 10.1093/rheumatology/ken136
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69221334</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/rheumatology/ken136</oup_id><sourcerecordid>1497465831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3</originalsourceid><addsrcrecordid>eNqNkctu1DAUhiMEohd4AiRkIdFdWl9yZTcqlCJVgLiLjeXYxx1PEzvYDjCPwtviIdGA2MDGtny-_z_2-bPsAcGnBLfszK9hGkR0vbvent2AJay6lR2SoqI5Zoze3p9pcZAdhbDBGJeENXezA9IURVM09DD7sbqGXMEIVoGNyNi16Uw0ziKnEcjoRiORFL002kixKzxBAo0uBNP1gLxLi3YeaYiTsfkKCauQCxHc6Gw0NjmiMemSeUDfTFyjzfQVrEkyBX73_GHrQuq4VH-1sukm3MvuaNEHuL_sx9n7i2fvzi_zq1fPX5yvrnKZPhNzCo2igEEIpTrZ6ragoigJ7agqRVdK1slOi6oqSYFBNSAVIU1ba42prKVS7Dg7mX1H775MECIfTJDQ98KCmwKvWkoJY8U_QYrrZMxYAh_9BW7c5G36BCdtWdVp9iRBbIakT8P0oPnozSD8lhPMd_nyP_Plc75J9XCxnroB1G_NEmgCHi-ACGmW2gsrTdhzFBc1rtqd0enMuWn8z875LDAp3O97ifA3vKpZXfLLT5_5m5dvL-qPH17zp-wn6DHXrw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195674481</pqid></control><display><type>article</type><title>Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis</title><source>Oxford Journals Online</source><source>Alma/SFX Local Collection</source><creator>Marhaug, G. ; Shah, V. ; Shroff, R. ; Varsani, H. ; Wedderburn, L. R. ; Pilkington, C. A. ; Brogan, P. A.</creator><creatorcontrib>Marhaug, G. ; Shah, V. ; Shroff, R. ; Varsani, H. ; Wedderburn, L. R. ; Pilkington, C. A. ; Brogan, P. A.</creatorcontrib><description>Objectives. To assess if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be associated with an increased risk of calcinosis in children with juvenile dermatomyositis (JDM). Methods. The frequency of calcinosis was derived from a national UK database of 212 cases of JDM. Serum fetuin-A and plasma osteopontin levels were determined using ELISA in 15 JDM patients with calcinosis and 15 JDM patients without calcinosis. Healthy controls were 19 age-matched children, 24 adolescents and 13 adults. Sixteen patients with juvenile idiopathic arthritis (JIA) were additional paediatric disease controls. Results. Of the 212 JDM cases 10% had calcinosis. Calcinosis patients had younger age of disease onset than those without calcinosis (mean age of 5.3 yrs vs 7.1 yrs, respectively, P = 0.016). No significant difference in fetuin-A or osteopontin could be detected between the two JDM groups. Fetuin-A levels in all groups of children and the adolescent group were much lower than described previously in adults, and there was a significant positive correlation between age and fetuin-A level, and also between osteopontin levels in plasma and serum fetuin-A. Conclusions. Children who develop JDM at an younger age may have increased risk of developing calcinosis. Physiologically low levels of fetuin-A in young children combined with an additional negative acute-phase effect on fetuin-A due to chronic inflammation could explain in part the propensity to develop ectopic calcification observed in JDM patients, and why calcinosis is less frequent in adults with dermatomyositis.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/ken136</identifier><identifier>PMID: 18448482</identifier><identifier>CODEN: BJRHDF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Age of Onset ; Aging - blood ; alpha-2-HS-Glycoprotein ; Biological and medical sciences ; Blood Proteins - analysis ; Blood Proteins - physiology ; Calcinosis ; Calcinosis - blood ; Calcinosis - etiology ; Case-Control Studies ; Child ; Child, Preschool ; Dermatomyositis - blood ; Dermatomyositis - complications ; Dermatomyositis - drug therapy ; Diseases of the osteoarticular system ; Fetuin-A ; Humans ; Juvenile dermatomyositis ; Medical sciences ; Metabolic diseases ; Metals (hemochromatosis...) ; Osteopontin ; Osteopontin - blood ; Osteopontin - physiology ; Other metabolic disorders ; Risk Factors ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><ispartof>Rheumatology (Oxford, England), 2008-07, Vol.47 (7), p.1031-1037</ispartof><rights>The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3</citedby><cites>FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20470696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18448482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marhaug, G.</creatorcontrib><creatorcontrib>Shah, V.</creatorcontrib><creatorcontrib>Shroff, R.</creatorcontrib><creatorcontrib>Varsani, H.</creatorcontrib><creatorcontrib>Wedderburn, L. R.</creatorcontrib><creatorcontrib>Pilkington, C. A.</creatorcontrib><creatorcontrib>Brogan, P. A.</creatorcontrib><title>Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Objectives. To assess if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be associated with an increased risk of calcinosis in children with juvenile dermatomyositis (JDM). Methods. The frequency of calcinosis was derived from a national UK database of 212 cases of JDM. Serum fetuin-A and plasma osteopontin levels were determined using ELISA in 15 JDM patients with calcinosis and 15 JDM patients without calcinosis. Healthy controls were 19 age-matched children, 24 adolescents and 13 adults. Sixteen patients with juvenile idiopathic arthritis (JIA) were additional paediatric disease controls. Results. Of the 212 JDM cases 10% had calcinosis. Calcinosis patients had younger age of disease onset than those without calcinosis (mean age of 5.3 yrs vs 7.1 yrs, respectively, P = 0.016). No significant difference in fetuin-A or osteopontin could be detected between the two JDM groups. Fetuin-A levels in all groups of children and the adolescent group were much lower than described previously in adults, and there was a significant positive correlation between age and fetuin-A level, and also between osteopontin levels in plasma and serum fetuin-A. Conclusions. Children who develop JDM at an younger age may have increased risk of developing calcinosis. Physiologically low levels of fetuin-A in young children combined with an additional negative acute-phase effect on fetuin-A due to chronic inflammation could explain in part the propensity to develop ectopic calcification observed in JDM patients, and why calcinosis is less frequent in adults with dermatomyositis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Aging - blood</subject><subject>alpha-2-HS-Glycoprotein</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - analysis</subject><subject>Blood Proteins - physiology</subject><subject>Calcinosis</subject><subject>Calcinosis - blood</subject><subject>Calcinosis - etiology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatomyositis - blood</subject><subject>Dermatomyositis - complications</subject><subject>Dermatomyositis - drug therapy</subject><subject>Diseases of the osteoarticular system</subject><subject>Fetuin-A</subject><subject>Humans</subject><subject>Juvenile dermatomyositis</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Osteopontin</subject><subject>Osteopontin - blood</subject><subject>Osteopontin - physiology</subject><subject>Other metabolic disorders</subject><subject>Risk Factors</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkctu1DAUhiMEohd4AiRkIdFdWl9yZTcqlCJVgLiLjeXYxx1PEzvYDjCPwtviIdGA2MDGtny-_z_2-bPsAcGnBLfszK9hGkR0vbvent2AJay6lR2SoqI5Zoze3p9pcZAdhbDBGJeENXezA9IURVM09DD7sbqGXMEIVoGNyNi16Uw0ziKnEcjoRiORFL002kixKzxBAo0uBNP1gLxLi3YeaYiTsfkKCauQCxHc6Gw0NjmiMemSeUDfTFyjzfQVrEkyBX73_GHrQuq4VH-1sukm3MvuaNEHuL_sx9n7i2fvzi_zq1fPX5yvrnKZPhNzCo2igEEIpTrZ6ragoigJ7agqRVdK1slOi6oqSYFBNSAVIU1ba42prKVS7Dg7mX1H775MECIfTJDQ98KCmwKvWkoJY8U_QYrrZMxYAh_9BW7c5G36BCdtWdVp9iRBbIakT8P0oPnozSD8lhPMd_nyP_Plc75J9XCxnroB1G_NEmgCHi-ACGmW2gsrTdhzFBc1rtqd0enMuWn8z875LDAp3O97ifA3vKpZXfLLT5_5m5dvL-qPH17zp-wn6DHXrw</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Marhaug, G.</creator><creator>Shah, V.</creator><creator>Shroff, R.</creator><creator>Varsani, H.</creator><creator>Wedderburn, L. R.</creator><creator>Pilkington, C. A.</creator><creator>Brogan, P. A.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis</title><author>Marhaug, G. ; Shah, V. ; Shroff, R. ; Varsani, H. ; Wedderburn, L. R. ; Pilkington, C. A. ; Brogan, P. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Aging - blood</topic><topic>alpha-2-HS-Glycoprotein</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - analysis</topic><topic>Blood Proteins - physiology</topic><topic>Calcinosis</topic><topic>Calcinosis - blood</topic><topic>Calcinosis - etiology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatomyositis - blood</topic><topic>Dermatomyositis - complications</topic><topic>Dermatomyositis - drug therapy</topic><topic>Diseases of the osteoarticular system</topic><topic>Fetuin-A</topic><topic>Humans</topic><topic>Juvenile dermatomyositis</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Osteopontin</topic><topic>Osteopontin - blood</topic><topic>Osteopontin - physiology</topic><topic>Other metabolic disorders</topic><topic>Risk Factors</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marhaug, G.</creatorcontrib><creatorcontrib>Shah, V.</creatorcontrib><creatorcontrib>Shroff, R.</creatorcontrib><creatorcontrib>Varsani, H.</creatorcontrib><creatorcontrib>Wedderburn, L. R.</creatorcontrib><creatorcontrib>Pilkington, C. A.</creatorcontrib><creatorcontrib>Brogan, P. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marhaug, G.</au><au>Shah, V.</au><au>Shroff, R.</au><au>Varsani, H.</au><au>Wedderburn, L. R.</au><au>Pilkington, C. A.</au><au>Brogan, P. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>47</volume><issue>7</issue><spage>1031</spage><epage>1037</epage><pages>1031-1037</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><coden>BJRHDF</coden><abstract>Objectives. To assess if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be associated with an increased risk of calcinosis in children with juvenile dermatomyositis (JDM). Methods. The frequency of calcinosis was derived from a national UK database of 212 cases of JDM. Serum fetuin-A and plasma osteopontin levels were determined using ELISA in 15 JDM patients with calcinosis and 15 JDM patients without calcinosis. Healthy controls were 19 age-matched children, 24 adolescents and 13 adults. Sixteen patients with juvenile idiopathic arthritis (JIA) were additional paediatric disease controls. Results. Of the 212 JDM cases 10% had calcinosis. Calcinosis patients had younger age of disease onset than those without calcinosis (mean age of 5.3 yrs vs 7.1 yrs, respectively, P = 0.016). No significant difference in fetuin-A or osteopontin could be detected between the two JDM groups. Fetuin-A levels in all groups of children and the adolescent group were much lower than described previously in adults, and there was a significant positive correlation between age and fetuin-A level, and also between osteopontin levels in plasma and serum fetuin-A. Conclusions. Children who develop JDM at an younger age may have increased risk of developing calcinosis. Physiologically low levels of fetuin-A in young children combined with an additional negative acute-phase effect on fetuin-A due to chronic inflammation could explain in part the propensity to develop ectopic calcification observed in JDM patients, and why calcinosis is less frequent in adults with dermatomyositis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>18448482</pmid><doi>10.1093/rheumatology/ken136</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1462-0324
ispartof Rheumatology (Oxford, England), 2008-07, Vol.47 (7), p.1031-1037
issn 1462-0324
1462-0332
language eng
recordid cdi_proquest_miscellaneous_69221334
source Oxford Journals Online; Alma/SFX Local Collection
subjects Adolescent
Adult
Age Factors
Age of Onset
Aging - blood
alpha-2-HS-Glycoprotein
Biological and medical sciences
Blood Proteins - analysis
Blood Proteins - physiology
Calcinosis
Calcinosis - blood
Calcinosis - etiology
Case-Control Studies
Child
Child, Preschool
Dermatomyositis - blood
Dermatomyositis - complications
Dermatomyositis - drug therapy
Diseases of the osteoarticular system
Fetuin-A
Humans
Juvenile dermatomyositis
Medical sciences
Metabolic diseases
Metals (hemochromatosis...)
Osteopontin
Osteopontin - blood
Osteopontin - physiology
Other metabolic disorders
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
title Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T21%3A52%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-dependent%20inhibition%20of%20ectopic%20calcification:%20a%20possible%20role%20for%20fetuin-A%20and%20osteopontin%20in%20patients%20with%20juvenile%20dermatomyositis%20with%20calcinosis&rft.jtitle=Rheumatology%20(Oxford,%20England)&rft.au=Marhaug,%20G.&rft.date=2008-07-01&rft.volume=47&rft.issue=7&rft.spage=1031&rft.epage=1037&rft.pages=1031-1037&rft.issn=1462-0324&rft.eissn=1462-0332&rft.coden=BJRHDF&rft_id=info:doi/10.1093/rheumatology/ken136&rft_dat=%3Cproquest_cross%3E1497465831%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c513t-2e8d2e0eaaddbc9f942a4512b2d5ab5c3bcbfa665140ed8ecd11897ff02c7cdd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=195674481&rft_id=info:pmid/18448482&rft_oup_id=10.1093/rheumatology/ken136&rfr_iscdi=true