significance of Treg cells in defective tumor immunity

Regulatory T cells (Treg) enriched in FoxP3⁺, glucocorticoid-induced TNF receptor⁺, and cytotoxic T-lymphocyte-associated antigen-4⁺ exert a potential to suppress effector T cells in the periphery. These cells exist in markedly higher proportions within tumor-infiltrating lymphocytes, peripheral blo...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2008-06, Vol.56 (3), p.181-191
Main Authors: Kosmaczewska, Agata, Ciszak, Lidia, Potoczek, Stanisław, Frydecka, Irena
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cell Proliferation
Cytokines - immunology
Cytokines - metabolism
Forkhead Transcription Factors - metabolism
FoxP3
Humans
Immune Tolerance
Immunology
immunosuppression
Ligands
Lymphocytes
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - metabolism
Neoplasms - immunology
Neoplasms - metabolism
Pharmacology/Toxicology
Review
T cell receptors
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - physiology
Treg cells
tumor immunity
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Summary:Regulatory T cells (Treg) enriched in FoxP3⁺, glucocorticoid-induced TNF receptor⁺, and cytotoxic T-lymphocyte-associated antigen-4⁺ exert a potential to suppress effector T cells in the periphery. These cells exist in markedly higher proportions within tumor-infiltrating lymphocytes, peripheral blood lymphocytes, and/or regional lymph node lymphocytes of patients with cancer and their frequencies are suggested to be strongly related to tumor progression and inversely correlated with the efficacy of treatment. Tumor-specific Treg cells require ligand-specific activation and cell-to-cell contact to exert their suppressive activity on tumor-specific effector cells (CD8⁺ cytotoxic T lymphocytes and CD4⁺ Th cells), which includes decreased cytotoxity, proliferation, and Th1 cytokine secrection. Depletion or blockade of Treg cells can enhance immune protection from tumor-associated antigens that are expressed as self antigens. Recent studies revealed that lymphoma T cells might adopt a Treg profile as well. Studies assessing the influence of chemotherapy on Treg cells have also been included in this review.
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-008-0018-1