Dosing study of remifentanil and propofol for tracheal intubation without the use of muscle relaxants

Sixty ASA I and II patients, premedicated with midazolam, were administered propofol 2 mg.kg−1 and remifentanil 3 μg.kg−1 (group R3), remifentanil 4 μg.kg−1 (group R4) and remifentanil 5 μg.kg−1 (group R5). Laryngoscopy and intubation were performed 1 min after the administration of the study drugs...

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Bibliographic Details
Published in:Anaesthesia 1999-11, Vol.54 (11), p.1037-1040
Main Authors: Alexander, R., Olufolabi, A. J., Booth, J., El‐Moalem, H. E., Glass, P. S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analgesics
Analgesics, opioid
remifentanil
Anesthetics, Combined - administration & dosage
Biological and medical sciences
Blood Pressure - physiology
Double-Blind Method
Female
General anaesthesia
Heart Rate - physiology
Humans
Intubation, Intratracheal
Intubation
tracheal
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Piperidines - administration & dosage
Propofol - administration & dosage
Remifentanil
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Summary:Sixty ASA I and II patients, premedicated with midazolam, were administered propofol 2 mg.kg−1 and remifentanil 3 μg.kg−1 (group R3), remifentanil 4 μg.kg−1 (group R4) and remifentanil 5 μg.kg−1 (group R5). Laryngoscopy and intubation were performed 1 min after the administration of the study drugs and the intubating conditions were assessed. Good to excellent conditions were observed in 12 patients in group R3 compared with 19 patients each in groups R4 and R5 (p = 0.004). Significant reductions in mean arterial pressure (MAP) and heart rate (HR) after administration of the study drug were observed in each group, p 
ISSN:0003-2409
1365-2044
DOI:10.1046/j.1365-2044.1999.00904.x