Hypercalcemia, chronic lymphocytic leukemia and multiple myeloma: uncommon association

A fifty-nine year old woman is admitted with severe hypercalcemia and other metabolic disorders. The buffy coat showed plasmoblasts in association with chronic lymphocytic leukemia cells (CLL). Immunophenotyping revealed different light chains on CLL cells and in plasmoblasts. We discuss the associa...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 1999-08, Vol.54 (4), p.217-219
Main Authors: Schoevaerdts, D, Mineur, P, Hennaux, V, Sibille, C
Format: Article
Language:English
Subjects:
Diagnosis, Differential
Fatal Outcome
Female
Gene Rearrangement
Humans
Hypercalcemia - complications
Immunoglobulin kappa-Chains - analysis
Immunophenotyping
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - pathology
Neoplasms, Multiple Primary - pathology
Plasma Cells - pathology
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Description
Summary:A fifty-nine year old woman is admitted with severe hypercalcemia and other metabolic disorders. The buffy coat showed plasmoblasts in association with chronic lymphocytic leukemia cells (CLL). Immunophenotyping revealed different light chains on CLL cells and in plasmoblasts. We discuss the association of hypercalcemia and CLL, its physiopathology and the distinction with Richter's Syndrome. We also review literature descriptions of the uncommon association of CLL and Multiple Myeloma and raise the question of its clonal origin.
ISSN:1784-3286
2295-3337
DOI:10.1080/17843286.1999.11754235