Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides

The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis. Lipopolysaccharide (LPS) is an important virulence determinant in Gram-nega...

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Bibliographic Details
Published in:Innate immunity (London, England) England), 2008-06, Vol.14 (3), p.127-144
Main Authors: De Soyza, Anthony, Silipo, Alba, Lanzetta, Rosa, Govan, John R, Molinaro, Antonio
Format: Article
Language:English
Subjects:
Animals
Burkholderia cepacia
Burkholderia cepacia complex - chemistry
Burkholderia cepacia complex - drug effects
Burkholderia cepacia complex - immunology
Burkholderia cepacia complex - pathogenicity
Burkholderia Infections - immunology
Burkholderia Infections - metabolism
Defensins - pharmacology
Drug Resistance, Bacterial - drug effects
Humans
Lipopolysaccharides - chemistry
Lipopolysaccharides - immunology
Signal Transduction
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Summary:The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis. Lipopolysaccharide (LPS) is an important virulence determinant in Gram-negative pathogens. In this review, we highlight important data within the field commenting on LPS/lipid A structure-to-function relationships and cytokine induction capacity of Burkholderia strains studied so far.
ISSN:1753-4259
DOI:10.1177/1753425908093984