Dendritic cell origins: Puzzles and paradoxes

In the present review, a series of studies on the origins of dendritic cells of mice and humans are summarized. Several subsets of mature dendritic cells found in vivo are described and these may correspond to distinct lineages. There is evidence that some dendritic cells are myeloid‐derived and tha...

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Bibliographic Details
Published in:Immunology and cell biology 1999-10, Vol.77 (5), p.411-419
Main Authors: Vandenabeele, Stéphane, Wu, Li
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cells, Cultured
dendritic cell development
Dendritic Cells - cytology
Dendritic Cells - immunology
Humans
Langerhans Cells - cytology
Langerhans Cells - immunology
lymphoid
Mice
myeloid
Phenotype
plasmacytoid T cells
Stem Cells - cytology
T-Lymphocytes - immunology
T-Lymphocytes - physiology
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Summary:In the present review, a series of studies on the origins of dendritic cells of mice and humans are summarized. Several subsets of mature dendritic cells found in vivo are described and these may correspond to distinct lineages. There is evidence that some dendritic cells are myeloid‐derived and that others are lymphoid‐derived. The different ways of generating dendritic cells are examined and an attempt to reconcile the differences seen using mouse and human culture models is made. The particular case of Langerhans cells is discussed and an historical overview of the biology of the plasmacytoid T cells, which may represent a distinct ‘lymphoid‐related’ dendritic cell lineage, is given. It is concluded that three or four different pathways lead to the development of different subtypes of dendritic cells.
ISSN:0818-9641
1440-1711
DOI:10.1046/j.1440-1711.1999.00857.x