Lesions in cattle exposed to Mycobacterium bovis-inoculated calves

Nine calves were housed for periods ranging from 24 to 117 days in close contact with cattle inoculated intranasally with Mycobacterium bovis. These "in-contact" calves were examined immunologically and bacteriologically during the period of exposure, and pathologically and immunocytochemi...

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Bibliographic Details
Published in:Journal of comparative pathology 1999-11, Vol.121 (4), p.321-337
Main Authors: Cassidy, J.P, Bryson, D.G, Pollock, J.M, Evans, R.T, Forster, F, Neill, S.D
Format: Article
Language:English
Subjects:
Animals
Antigens, Bacterial - analysis
Bacterial Vaccines - immunology
calves
Cattle
disease models
disease transmission
Disease Transmission, Infectious - veterinary
environmental exposure
histopathology
Immunoenzyme Techniques - veterinary
Interferon-gamma - blood
interferons
lesions
Lung - microbiology
Lung - pathology
lungs
lymph nodes
Lymph Nodes - microbiology
Lymph Nodes - pathology
Lymphocyte Activation
lymphocyte proliferation
Male
Mucus - microbiology
Mycobacterium bovis
Mycobacterium bovis - immunology
Mycobacterium bovis - isolation & purification
Mycobacterium bovis - pathogenicity
Nasal Mucosa - microbiology
Orchiectomy
pathogenesis
Tuberculosis, Bovine - immunology
Tuberculosis, Bovine - microbiology
Tuberculosis, Bovine - pathology
Tuberculosis, Bovine - transmission
Vaccination
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Summary:Nine calves were housed for periods ranging from 24 to 117 days in close contact with cattle inoculated intranasally with Mycobacterium bovis. These "in-contact" calves were examined immunologically and bacteriologically during the period of exposure, and pathologically and immunocytochemically post mortem. Three became infected by day 14, as indicated by the detection of M. bovis in nasal mucus. In-vitro interferon-gamma production and lymphocyte proliferation were detected after stimulation of peripheral blood with M. bovis antigens in the majority of in-contact animals by day 28; this provided support for the role of immunological mechanisms in pathogenesis. Tuberculous lesions were found in the submandibular and bronchomediastinal lymph nodes and in the lungs of the in-contact calves; in distribution and appearance the lesions resembled those observed in naturally occurring disease. The distribution of M. bovis antigen and the numbers of mycobacteria within pulmonary lesions are reported. 1999 Harcourt Publishers Ltd.
ISSN:0021-9975
1532-3129
DOI:10.1053/jcpa.1999.0330