Founder effect of the BRCA1 5382insC mutation in Brazilian patients with hereditary breast ovary cancer syndrome

Abstract The 5382insC mutation in BRCA1 is a frequently reported mutation, being very prevalent in Central and Eastern Europe. This mutation was recurrently reported in Brazil and one case was reported Portugal, but not in Spain and other South-American countries,. We analyzed the haplotypic profile...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2008-07, Vol.184 (1), p.62-66
Main Authors: da Costa, E.C.B, Vargas, F.R, Moreira, A.S, Lourenço, J.J, Caleffi, M, Ashton-Prolla, P, Martins Moreira, M.A.M
Format: Article
Language:English
Subjects:
Adult
Base Sequence
Brazil
Breast Neoplasms - genetics
DNA Primers
Female
Founder Effect
Genes, BRCA1
Haplotypes
Hematology, Oncology and Palliative Medicine
Humans
Medical Education
Middle Aged
Mutation
Ovarian Neoplasms - genetics
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Summary:Abstract The 5382insC mutation in BRCA1 is a frequently reported mutation, being very prevalent in Central and Eastern Europe. This mutation was recurrently reported in Brazil and one case was reported Portugal, but not in Spain and other South-American countries,. We analyzed the haplotypic profile of seven Brazilian carriers of 5382insC to characterize a possible founder effect. The analyses indicated that mutation carriers shared an identical haplotype. The absence of this mutation in Spain, other South American countries, and sub-Saharan populations, as well as the patients’ own ancestry, point to a significant Central or Eastern European contribution to the present genetic background of Brazilian population, different from the population structuring of remaining South American countries.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2008.03.011