Cell-penetrating peptides as delivery vehicles for biology and medicine

Cell-penetrating peptides (CPPs) have found numerous applications in biology and medicine since the first synthetic cell-permeable sequence was identified two decades ago. Numerous types of drugs have been transported into cells using CPPs, including small-molecule pharmaceuticals, therapeutic prote...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2008-07, Vol.6 (13), p.2242-2255
Main Authors: Stewart, Kelly M, Horton, Kristin L, Kelley, Shana O
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cells - cytology
Cells - metabolism
Drug Carriers - chemistry
Drug Carriers - metabolism
Humans
Molecular Sequence Data
Nucleic Acids - metabolism
Nucleic Acids - therapeutic use
Organelles - metabolism
Peptides - chemistry
Peptides - metabolism
Proteins - metabolism
Proteins - therapeutic use
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Summary:Cell-penetrating peptides (CPPs) have found numerous applications in biology and medicine since the first synthetic cell-permeable sequence was identified two decades ago. Numerous types of drugs have been transported into cells using CPPs, including small-molecule pharmaceuticals, therapeutic proteins, and antisense oligonucleotides. Improved agents for medical imaging have been generated by conjugation with CPPs, with the appended peptides promoting cellular uptake and in some cases, cell-type specificity. Organelle-specific CPPs have also been generated, providing a means to target specific subcellular sites. This review highlights achievements in this area and illustrates the numerous examples where peptide chemistry was exploited as a means to provide new tools for biology and medicine.
ISSN:1477-0520
DOI:10.1039/b719950c