Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives

We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. The c.677C...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2008-07, Vol.32 (5), p.1331-1337
Main Authors: Ozbek, Zeynep, Kucukali, Cem Ismail, Ozkok, Elif, Orhan, Nurcan, Aydin, Makbule, Kilic, Gamze, Sazci, Ali, Kara, Ihsan
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - genetics
Bipolar disorders
Family
Female
Fluorescence Polarization Immunoassay - methods
Folic Acid - blood
Gene Frequency
Genotype
Homocysteine
Homocystine - blood
Humans
Male
Medical sciences
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Mood disorders
MTHFR
Neuropharmacology
Pharmacology. Drug treatments
Polymorphism, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Relatives
Vitamin B 12 - blood
Vitamin B12
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Summary:We investigated the effect of polymorphic variants of c.1298A>C (Glu429Ala) and c.677C>T (Ala222Val) in methylenetetrahydrofolate (MTHFR) gene on the total homocysteine (tHcy), folate and B12 levels in patients with bipolar disorder, first-degree relatives of patients, and controls. The c.677C>T and c.1298A>C polymorphisms in MTHFR were determined by polymerase chain reaction-restriction fragment length polymorphism in 197 bipolar patients, 278 relatives and 238 controls. tHcy and folate and vitamin B12 levels were measured by Fluorescence Polarization Immunoassay and Electrochemiluminescence, respectively. The tHcy was significantly increased in patients and relatives. In contrast, folate and B12 were significantly lower in patients and relatives. Gender was not considered as a significant determinant in the multivariate analysis. Genotypes of c.1298A>C and c.677C>T were correlated with tHcy, folate and B12. Patients and relatives carrying TT and/or AA and AC genotypes had elevated tHcy and reduced folate and B12 levels. High tHcy but low folate and vitamin B12 levels may be a risk factor for development of bipolar disorder.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2008.04.016