Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine

We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2008-07, Vol.32 (5), p.1277-1282
Main Authors: Calzavara, Mariana Bendlin, Andersen, Monica Levy, Fukushiro, Daniela Fukue, Lopez, Giorgia Batlle, Abílio, Vanessa Costhek, Tufik, Sergio, Frussa-Filho, Roberto
Format: Article
Language:English
Subjects:
Amphetamine
Amphetamine - pharmacology
Analysis of Variance
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Central Nervous System Stimulants - pharmacology
Conditioning
Conditioning (Psychology) - drug effects
Context-dependent behavioural sensitization
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Locomotion - drug effects
Locomotion - physiology
Male
Medical sciences
Mice
Mice, Inbred C57BL
Motor Activity - drug effects
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Paradoxical sleep deprivation
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Sleep rebound
Sleep, REM - drug effects
Sleep, REM - physiology
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Summary:We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-induced behavioural sensitization.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2008.04.001