Immunosuppression of EAMG by IVIG Is Mediated by a Disease-specific Anti-immunoglobulin Fraction

Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2008-06, Vol.1132 (1), p.244-248
Main Authors: Fuchs, Sara, Feferman, Tali, Meidler, Roberto, Margalit, Raanan, Sicsic, Camille, Brenner, Talma, Laub, Orgad, Souroujon, Miriam C.
Format: Article
Language:English
Subjects:
Animals
Antibody Specificity - immunology
experimental autoimmune myasthenia gravis (EAMG)
fractionation
Humans
Immunoglobulins, Intravenous - immunology
Immunoglobulins, Intravenous - therapeutic use
Immunosuppressive Agents - immunology
Immunosuppressive Agents - therapeutic use
Immunotherapy
intravenous immunoglobulin (IVIG)
myasthenia gravis (MG)
Myasthenia Gravis, Autoimmune, Experimental - immunology
Myasthenia Gravis, Autoimmune, Experimental - therapy
Rats
Receptors, Cholinergic - immunology
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Summary:Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIG) on immobilized IgG, isolated from rats with EAMG or from MG patients, results in a depletion of the suppressive activity of the IVIG. Moreover, reconstitution of the activity‐depleted IVIG with the eluted minute IVIG fractions that had been adsorbed onto the EAMG‐ or MG‐specific columns recovers the depleted immunosuppressive activity. This study supports the notion that the therapeutic effect of IVIG is mediated by an antigen‐specific anti‐immunoglobulin (anti‐idiotypic) activity that is essential for its suppressive activity.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1405.032