Waist circumference correlates with hepatic fat accumulation in male Japanese patients with non-alcoholic fatty liver disease, but not in females

Background and Aim:  Abdominal obesity, a component of metabolic syndrome, is a major risk factor for non‐alcoholic fatty liver disease (NAFLD). In recent worldwide definitions of metabolic syndrome, waist measurement has been proposed as a simple and useful estimate of abdominal obesity, taking int...

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Published in:Journal of gastroenterology and hepatology 2008-06, Vol.23 (6), p.908-913
Main Authors: Ishibashi, Eriko, Eguchi, Yuichiro, Eguchi, Takahisa, Matsunobu, Aki, Oza, Noriko, Nakashita, Shunya, Kitajima, Yoichiro, Kuroki, Shigetaka, Ozaki, Iwata, Kawaguchi, Yasunori, Ide, Yasushi, Yasutake, Tsutomu, Iwakiri, Ryuichi, Mizuta, Toshihiko, Ono, Naofumi, Fujimoto, Kazuma
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Body Fat Distribution
Body Mass Index
Cross-Sectional Studies
fatty liver
Fatty Liver - diagnostic imaging
Fatty Liver - etiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
gender difference
Hepatitis B virus
Hepatitis C virus
Humans
Intra-Abdominal Fat - diagnostic imaging
Japan
Liver Function Tests
liver spleen ratio
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Obesity - complications
Odds Ratio
Other diseases. Semiology
Radiography
Risk Factors
Sex Characteristics
Ultrasonography
visceral fat
waist circumference
Waist-Hip Ratio
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Summary:Background and Aim:  Abdominal obesity, a component of metabolic syndrome, is a major risk factor for non‐alcoholic fatty liver disease (NAFLD). In recent worldwide definitions of metabolic syndrome, waist measurement has been proposed as a simple and useful estimate of abdominal obesity, taking into account gender differences in waist circumference. The present cross‐sectional study investigated the correlation of hepatic fat accumulation and waist circumference in Japanese NAFLD patients to determine if there are gender differences in this relationship. Methods:  Consecutive patients (n = 2111) who had at least one of two criteria for liver disease (alanine aminotransferase [ALT] level >30 IU/mL and aspartate aminotransferase [AST]/ALT ratio 20 g/day were excluded. Patients with NAFLD underwent abdominal computed tomography. Hepatic fat accumulation was estimated by liver/spleen attenuation ratio (L/S ratio) and visceral adipose accumulation was measured as visceral fat area (VFA) at the umbilical level. Results:  Of the 221 NAFLD patients, 103 were females. In males, the relationship between L/S ratio and waist circumference was negative (r =−0.356, P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2008.05366.x