The future of the quinolones

This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent effi...

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Bibliographic Details
Published in:Drugs (Basel) 1999, Vol.58 (Supplement 2), p.1-5
Main Author: ANDRIOLE, V. T
Format: Article
Language:English
Subjects:
4-Quinolones
Animals
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Biological and medical sciences
Humans
Medical sciences
Pharmacology. Drug treatments
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Summary:This review emphasises the advances in the development of newer quinolones: their broader antimicrobial activity particularly their increased activity against Pneumococcus and anaerobes; their longer half-life and tissue penetration including activity in cerebrospinal fluid; and their excellent efficacy in respiratory, intra-abdominal, pelvic, and skin and soft tissue infections. Also, considerable progress has been made in our understanding of the development of bacterial resistance to the newer quinolones. Additional advances in quinolone development are likely to provide better compounds for clinical use.
ISSN:0012-6667
1179-1950
DOI:10.2165/00003495-199958002-00001