Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study

Abstract Procalcitonin serum level has been recommended as a new marker of bacterial infectious diseases. The aim of this prospective, multicenter study was to determine the clinical usefulness of procalcitonin in differentiating patients with sepsis from those with severe sepsis. Eighty-two patient...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2008, Vol.14 (3), p.244-249
Main Authors: Endo, Shigeatsu, Aikawa, Naoki, Fujishima, Seitaro, Sekine, Isao, Kogawa, Kazuhiro, Yamamoto, Yasuhiro, Kushimoto, Shigeki, Yukioka, Hidekazu, Kato, Noboru, Totsuka, Kyoichi, Kikuchi, Ken, Ikeda, Toshiaki, Ikeda, Kazumi, Yamada, Hiroyuki, Harada, Kazuaki, Satomura, Shinji
Format: Article
Language:English
Subjects:
APACHE
APACHE II score
beta-Glucans - blood
Biomarkers - blood
C-Reactive Protein - metabolism
Calcitonin - blood
Calcitonin Gene-Related Peptide
Endotoxins - blood
Glycoproteins - blood
Hematology, Oncology and Palliative Medicine
Humans
Infectious Diseases
Interleukin-6 - blood
Medical Microbiology
Medicine
Medicine & Public Health
Original Article
Predictive Value of Tests
Procalcitonin
Prospective Studies
Protein Precursors - blood
Sepsis
Sepsis - blood
Sepsis - diagnosis
Severity of Illness Index
SIRS
SOFA score
Virology
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Summary:Abstract Procalcitonin serum level has been recommended as a new marker of bacterial infectious diseases. The aim of this prospective, multicenter study was to determine the clinical usefulness of procalcitonin in differentiating patients with sepsis from those with severe sepsis. Eighty-two patients were enrolled: 20 without systemic inflammatory response syndrome (SIRS), 9 with SIRS, 34 with sepsis, and 19 with severe sepsis. The patients with severe sepsis had significantly higher procalcitonin levels (median, 36.1 ng/ml) than those with sepsis (median, 0.6 ng/ml). With a procalcitonin cutoff value of 2.0 ng/ml, sensitivity for the detection of severe sepsis and specificity for the detection of sepsis were 94.7% and 78.1%, respectively. A good correlation was found between the serum procalcitonin level and the Sepsis-Related Organ Failure Assessment (SOFA) score ( r = 0.680), although no correlation was found between the C-reactive protein (CRP) level and the SOFA score. In conclusion, the procalcitonin serum level may be useful not only for aiding the diagnosis of sepsis but also for discriminating between sepsis and severe sepsis.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-008-0608-1