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Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder

Linkage of attention deficit hyperactivity disorder (ADHD) to the short arm‐centromeric region of chromosome 5 has been reported in multiple studies. The overlapping region (5p13‐q11) contains a number of strong candidate genes for ADHD, based on their role in brain function or neurodevelopment. The...

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Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2008-07, Vol.147B (5), p.600-605
Main Authors: Laurin, Nancy, Lee, Jonghun, Ickowicz, Abel, Pathare, Tejaswee, Malone, Molly, Tannock, Rosemary, Kennedy, James L., Schachar, Russell J., Barr, Cathy L.
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description Linkage of attention deficit hyperactivity disorder (ADHD) to the short arm‐centromeric region of chromosome 5 has been reported in multiple studies. The overlapping region (5p13‐q11) contains a number of strong candidate genes for ADHD, based on their role in brain function or neurodevelopment. The aim of this study was to investigate some of the top candidates among these genes in relation to ADHD in a sample of 245 nuclear families from the Toronto area. We investigated the genes for the glial cell‐derived neurotropic factor (GDNF), the fibroblast growth factor 10 (FGF10), islet‐1 (ISL1), the hyperpolarized potassium channel (HCN1) and the integrin alpha 1 (ITGA1). In addition to these genes, we assessed the 3′region of the SLC1A3 gene, a glutamate transporter implicated in ADHD by a previous association study. A total of 36 polymorphisms were selected across the six genes. We performed family‐based association and haplotype analyses. ADHD is a dimensional disorder, with symptoms of inattention and hyperactivity‐impulsivity therefore, we also conducted quantitative analysis in relation to symptom scores for both dimensions. Single marker and haplotype analyses yielded little evidence of association for any of the genes tested in this study. Moreover, we were unable to replicate the positive association findings reported for SLC1A3. Our results suggest that these six genes are unlikely to be susceptibility genes in the chromosome 5p13‐q11 region and other genes should now be considered for priority study. © 2007 Wiley‐Liss, Inc.
doi_str_mv 10.1002/ajmg.b.30654
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ispartof American journal of medical genetics. Part B, Neuropsychiatric genetics, 2008-07, Vol.147B (5), p.600-605
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1552-485X
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subjects 5p13-q11
ADHD
Adolescent
Alleles
Attention Deficit Disorder with Hyperactivity - genetics
Biological and medical sciences
candidate genes
Child
Chromosomes, Human, Pair 5 - genetics
Classical genetics, quantitative genetics, hybrids
Female
Fundamental and applied biological sciences. Psychology
Genetic Markers
Genetic Predisposition to Disease
genetics
Genetics of eukaryotes. Biological and molecular evolution
Haplotypes
Human
Humans
Linkage Disequilibrium
Male
Medical genetics
Medical sciences
Polymorphism, Single Nucleotide
TDT
title Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder
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