Chronic lymphocytic leukaemia and neuroendocrine cancer

We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin...

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Bibliographic Details
Published in:British journal of haematology 1999-06, Vol.105 (4), p.989-992
Main Authors: Russo, F., Guadagni, S., Corazzelli, G., Frigeri, F., Monda, V. M., Abate, G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
chromosome 3 deletion
Chromosome Deletion
Chromosomes, Human, Pair 3 - genetics
chronic lymphocytic leukaemia
Fatal Outcome
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocytes, Mononuclear - pathology
Male
Medical sciences
Middle Aged
neuroendocrine cancer
stopflow therapy
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Summary:We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of > 75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1999.01472.x