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Chronic lymphocytic leukaemia and neuroendocrine cancer
We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin...
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| Published in: | British journal of haematology 1999-06, Vol.105 (4), p.989-992 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| container_end_page | 992 |
| container_issue | 4 |
| container_start_page | 989 |
| container_title | British journal of haematology |
| container_volume | 105 |
| creator | Russo, F. Guadagni, S. Corazzelli, G. Frigeri, F. Monda, V. M. Abate, G. |
| description | We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of > 75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL.
At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known. |
| doi_str_mv | 10.1046/j.1365-2141.1999.01472.x |
| format | article |
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At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1999.01472.x</identifier><identifier>PMID: 10554811</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; chromosome 3 deletion ; Chromosome Deletion ; Chromosomes, Human, Pair 3 - genetics ; chronic lymphocytic leukaemia ; Fatal Outcome ; Hematologic and hematopoietic diseases ; Humans ; Karyotyping ; Leukemia, Lymphocytic, Chronic, B-Cell - complications ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocytes, Mononuclear - pathology ; Male ; Medical sciences ; Middle Aged ; neuroendocrine cancer ; stopflow therapy</subject><ispartof>British journal of haematology, 1999-06, Vol.105 (4), p.989-992</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3892-11038497685c0eff803b121e2e34bf3f592f42c486f2f7a5af68d55cb12288a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1866217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10554811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russo, F.</creatorcontrib><creatorcontrib>Guadagni, S.</creatorcontrib><creatorcontrib>Corazzelli, G.</creatorcontrib><creatorcontrib>Frigeri, F.</creatorcontrib><creatorcontrib>Monda, V. M.</creatorcontrib><creatorcontrib>Abate, G.</creatorcontrib><title>Chronic lymphocytic leukaemia and neuroendocrine cancer</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of > 75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL.
At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.</description><subject>Biological and medical sciences</subject><subject>chromosome 3 deletion</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Human, Pair 3 - genetics</subject><subject>chronic lymphocytic leukaemia</subject><subject>Fatal Outcome</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - complications</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neuroendocrine cancer</subject><subject>stopflow therapy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0EoqXwCygLxC7B41ecBQuoeKoSG1hbrmOrKXkUuxHN35OQCliymivNuTPSQSgCnABm4mqdABU8JsAggSzLEgwsJcnuAE1_FodoijFO474gJ-gkhDXGQDGHYzQBzDmTAFOUzle-qQsTlV21WTWm2w7Ztu_aVoWOdJ1HtW19Y-u8Mb6obWR0baw_RUdOl8Ge7ecMvd3fvc4f48XLw9P8ZhEbKjMSA2AqWZYKyQ22zklMl0DAEkvZ0lHHM-IYMUwKR1yquXZC5pybHiJSakln6HK8u_HNR2vDVlVFMLYsdW2bNiiRESYwznpQjqDxTQjeOrXxRaV9pwCrQZpaq8GNGtyoQZr6lqZ2ffV8_6NdVjb_Uxwt9cDFHtDB6NL5XkERfjkpBIG0x65H7LMobffv_-r2-XFI9AttjYZj</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Russo, F.</creator><creator>Guadagni, S.</creator><creator>Corazzelli, G.</creator><creator>Frigeri, F.</creator><creator>Monda, V. 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Myelofibrosis</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neuroendocrine cancer</topic><topic>stopflow therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russo, F.</creatorcontrib><creatorcontrib>Guadagni, S.</creatorcontrib><creatorcontrib>Corazzelli, G.</creatorcontrib><creatorcontrib>Frigeri, F.</creatorcontrib><creatorcontrib>Monda, V. 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M.</au><au>Abate, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic lymphocytic leukaemia and neuroendocrine cancer</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1999-06</date><risdate>1999</risdate><volume>105</volume><issue>4</issue><spage>989</spage><epage>992</epage><pages>989-992</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of > 75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL.
At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>10554811</pmid><doi>10.1046/j.1365-2141.1999.01472.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 1999-06, Vol.105 (4), p.989-992 |
| issn | 0007-1048 1365-2141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69246009 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Biological and medical sciences chromosome 3 deletion Chromosome Deletion Chromosomes, Human, Pair 3 - genetics chronic lymphocytic leukaemia Fatal Outcome Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Lymphocytic, Chronic, B-Cell - complications Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes, Mononuclear - pathology Male Medical sciences Middle Aged neuroendocrine cancer stopflow therapy |
| title | Chronic lymphocytic leukaemia and neuroendocrine cancer |
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