Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis

Abstract COMT gene is a logical candidate gene for schizophrenia. Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls. In this study, using an epidemiological...

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Bibliographic Details
Published in:Schizophrenia research 2008-07, Vol.102 (1), p.206-209
Main Authors: Mata, Ignacio, Perez-Iglesias, Rocio, Pelayo-Teran, Jose Maria, Rodríguez-Sanchez, Jose Manuel, Gonzalez-Blanch, Cesar, Carrasco-Marin, Eugenio, Vazquez-Barquero, Jose Luis, Crespo-Facorro, Benedicto
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - therapeutic use
Catechol O-Methyltransferase - genetics
Catechol O-Methyltransferase - metabolism
Cognition
Cognition Disorders - diagnosis
Cognition Disorders - genetics
COMT
Diagnostic and Statistical Manual of Mental Disorders
Female
First-episode
Genetic Predisposition to Disease - genetics
Genotype
Humans
Longitudinal Studies
Male
Methionine - genetics
Neuropsychological Tests - statistics & numerical data
Phenotype
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Psychiatric Status Rating Scales
Psychiatry
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - drug therapy
Psychotic Disorders - genetics
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenia - genetics
Schizophrenic Psychology
Valine - genetics
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Summary:Abstract COMT gene is a logical candidate gene for schizophrenia. Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls. In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2008.02.011