Clinical Immunology Review Series: An approach to the patient with anaphylaxis

Summary Anaphylaxis is a severe, life‐threatening, generalized or systemic hypersensitivity reaction. While there is agreement as to this definition of anaphylaxis, the clinical presentation is often variable and it is not uncommon for there to be debate after the event as to whether anaphylaxis had...

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Bibliographic Details
Published in:Clinical and experimental immunology 2008-07, Vol.153 (1), p.1-9
Main Authors: El‐Shanawany, T., Williams, P. E., Jolles, S.
Format: Article
Language:English
Subjects:
adrenaline
Adrenergic Agonists - therapeutic use
Allergens - immunology
allergy
Analytical, structural and metabolic biochemistry
anaphylaxis
Anaphylaxis - drug therapy
Anaphylaxis - immunology
Biological and medical sciences
Emergencies
Epinephrine - therapeutic use
Fundamental and applied biological sciences. Psychology
Humans
IgE antibody
Immunoglobulin E - immunology
Molecular biophysics
tryptase
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Summary:Summary Anaphylaxis is a severe, life‐threatening, generalized or systemic hypersensitivity reaction. While there is agreement as to this definition of anaphylaxis, the clinical presentation is often variable and it is not uncommon for there to be debate after the event as to whether anaphylaxis had actually occurred. The management of anaphylaxis falls into two distinct phases: (1) emergency treatment and resuscitation of a patient with acute anaphylaxis and (2) the search for a cause for the event and the formulation of a plan to prevent and treat possible further episodes of anaphylaxis. Both aspects are important in preventing death from anaphylaxis and are covered in this review.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2008.03694.x