Cardiovascular Risk Evaluated by C-Reactive Protein Levels in Diabetic and Obese Mexican Subjects

Background Previous studies have reported elevated levels of C-reactive protein (CRP) in obese and diabetic subjects, but it is unclear whether both these conditions have an additive effect on the variability of serum CRP levels. Methods and Results The study enrolled 385 men and women who were clas...

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Published in:Circulation Journal 2008, Vol.72(7), pp.1170-1174
Main Authors: Flores-Alfaro, Eugenia, Parra-Rojas, Isela, Salgado-Bernabé, Aralia B, Chávez-Maldonado, Juan P, Salazar-Martinez, Eduardo
Format: Article
Language:English
Subjects:
Adult
Aged
Body Mass Index
C-Reactive Protein - metabolism
Coronary Disease - ethnology
Coronary Disease - immunology
Diabetes mellitus
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - immunology
Female
Heart disease
Humans
Inflammation
Inflammation - blood
Inflammation - ethnology
Interleukin-6 - blood
Linear Models
Male
Mexico - epidemiology
Middle Aged
Obesity
Obesity - ethnology
Obesity - immunology
Platelet Count
Risk Factors
Waist-Hip Ratio
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Summary:Background Previous studies have reported elevated levels of C-reactive protein (CRP) in obese and diabetic subjects, but it is unclear whether both these conditions have an additive effect on the variability of serum CRP levels. Methods and Results The study enrolled 385 men and women who were classified into 4 groups: (1) diabetes (n=97), (2) obesity (n=108), (3) diabetes/obesity (n=78), and (4) healthy (n=102). All were Mexican subjects from Guerrero State. Serum high-sensitivity CRP (hs-CRP) levels were higher in both type 2 diabetes mellitus (T2DM)/obesity and obesity (5.1 mg/L) groups than in the diabetics (1.8 mg/L) without obesity. Only the measurements of obesity were strongly related to hs-CRP (body mass index, r=0.46 and waist circumference, r=0.41). The presence of T2DM and obesity explain 20% of the circulating hs-CRP level, following waist circumference (16%), leukocyte count (10%), diastolic blood pressure (6%), and female gender (4%). Obese subjects (odds ratio (OR)=6.3) and T2DM/obesity patients (OR=6.9) showed high risk for coronary disease and this effect was increased in T2DM/obesity women (OR=9.9). Also, abdominal obesity was associated with high coronary disease risk (OR=5.4), showing an increase in women (OR=7.3). Conclusion High hs-CRP levels are related to obesity and central distribution of body fat, leading to a higher cardiovascular risk among Mexican subjects. (Circ J 2008; 72: 1170 - 1174)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.72.1170