Erythropoietin and the endothelium - a promising link?

SUMMARY The major physiological function of erythropoietin (EPO) is thought to be the induction of erythropoiesis. However, a growing body of evidence indicates that EPO as well as recombinant human erythropoietin (rHuEPO) and its analogues have tissue‐protective effects and prevent tissue damage du...

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Bibliographic Details
Published in:European journal of clinical investigation 2008-07, Vol.38 (7), p.457-461
Main Authors: Fliser, D., Bahlmann, F. H.
Format: Article
Language:English
Subjects:
AKT activation
Biological and medical sciences
Cell Differentiation - physiology
Endothelial Cells - metabolism
Endothelium - metabolism
erythropoietin (EPO)
Erythropoietin - metabolism
General aspects
Humans
Medical sciences
nitric oxide
Nitric Oxide - metabolism
Protein-Serine-Threonine Kinases - metabolism
Receptors, Erythropoietin - metabolism
Signal Transduction - physiology
Vascular Diseases - metabolism
Vascular Diseases - prevention & control
vascular protection
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Summary:SUMMARY The major physiological function of erythropoietin (EPO) is thought to be the induction of erythropoiesis. However, a growing body of evidence indicates that EPO as well as recombinant human erythropoietin (rHuEPO) and its analogues have tissue‐protective effects and prevent tissue damage during ischaemia. This mini review summarizes the present knowledge on protective vascular effects of EPO and discusses the potential underlying mechanisms.
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2008.01968.x