Adenosine Tc-99m Tetrofosmin SPECT in Differentiation of Ischemic From Nonischemic Cardiomyopathy in Patients With LV Systolic Dysfunction

BACKGROUND:The noninvasive differentiation of ischemic from nonischemic cardiomyopathy is clinically important. However, whether adenosine Tc-99m tetrofosmin SPECT can offer clear and accurate information was not known. The aim of this study is to investigate the usefulness of adenosine Tc-99m tetro...

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Published in:Clinical nuclear medicine 2008-07, Vol.33 (7), p.459-463
Main Authors: Her, Sung Ho, Yoon, Hee Jeoung, Lee, Jong Min, Jin, Seung Won, Youn, Ho Joong, Seung, Ki Bae, Kim, Jae Hyung
Format: Article
Language:English
Subjects:
Aged
Cardiomyopathies - diagnosis
Cardiomyopathies - pathology
Coronary Angiography - methods
Echocardiography - methods
Female
Heart Failure - diagnosis
Heart Failure - pathology
Humans
Male
Middle Aged
Myocardial Ischemia - diagnosis
Myocardial Ischemia - pathology
Organophosphorus Compounds
Organotechnetium Compounds
Radiopharmaceuticals
Systole
Tomography, Emission-Computed, Single-Photon - instrumentation
Tomography, Emission-Computed, Single-Photon - methods
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - pathology
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Summary:BACKGROUND:The noninvasive differentiation of ischemic from nonischemic cardiomyopathy is clinically important. However, whether adenosine Tc-99m tetrofosmin SPECT can offer clear and accurate information was not known. The aim of this study is to investigate the usefulness of adenosine Tc-99m tetrofosmin SPECT in differentiation of ischemic from nonischemic etiology in patients with mild to severe LV systolic dysfunction and to compare the relationship between patients with mild LV systolic dysfunction and those with severe LV systolic dysfunction. METHODS:Seventy-five patients with chronic heart failure (LV ejection fraction ≤50%) underwent adenosine Tc-99m tetrofosmin SPECT and coronary angiography to identify ischemia. The patients were divided into 2 groups based on the result of ejection fraction (EF); group I (44 patients) had mild LV dysfunction, LVEF >35%, group II (31 patients) had severe LV dysfunction, LVEF ≤35%. As the result of SPECT, percent abnormal myocardium was categorized into 3 groupssmall defect,
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0b013e3181779271