Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation

• Published in: Journal of the renin-angiotensin-aldosterone system 2008-06, Vol.9 (2), p.107-111
• Main Authors: Sekuri, Cevad, Utuk, Ozan, Bayturan, Ozgur, Bilge, Ali, Kurhan, Ziya, Tavli, Talat
• Format: Article
• Language: English
• Subjects: Adult; Aged; Angiotensin II Type 1 Receptor Blockers - therapeutic use; Chronic Disease; Electrocardiography; Exercise Test; Exercise Tolerance - drug effects; Female; Heart Function Tests; Humans; Losartan - therapeutic use; Male; Middle Aged; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - drug therapy; Mitral Valve Insufficiency - physiopathology; Prospective Studies; Stroke Volume - physiology; Ultrasonography; Ventricular Function, Left - physiology
• ISSN: 1470-3203; 1752-8976
• DOI: 10.3317/jraas.2008.016

Objectives. The aim of this study was to assess the effects of losartan treatment on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation (MR) secondary to mitral valve prolapse or rheumatic heart disease. Methods. Twenty-seven patients (14 males, 13 females, mean age 51±11, range 21—76) with moderate MR due to mitral valve prolapse or rheumatic heart disease were examined by means of Doppler echocardiography.The subjects were submitted to treadmill exercise tests using the modified Bruce protocol at baseline, after six hours and after the six-week treatment period to be evaluated based on their exercise tolerance. Mitral Regurgitant Volume (MRV), effective regurgitant orifice diameter, left atrial volume, left ventricle (LV) end-diastolic volume index, LV end-systolic volume index, LV ejection fraction (LVEF), left ventricle mass index were calculated at baseline and after six weeks of treatment with single dose of losartan (50 mg/day). Results. Total treadmill exercise time increased from 477.7±147.9 to 535.7±149.0 seconds after six hours (p