The activity of gas metabolism, thermoregulation, and antioxidant enzymes in aging C57Bl/6 mice

The distribution type and correlative links between physiological and biochemical indices characterizing functional condition of the systems of gaseous exchange (V(O2) and V(CO2)), thermoregulation (body temperature and coefficient of thermoconductivity) and antioxidant defense have been studied in...

Full description

Saved in:
Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2008, Vol.54 (2), p.75-81
Main Authors: Utko, N O, Pishel', I M, Bezrukov, V V, Muradian, Kh K
Format: Article
Language:Ukrainian
Subjects:
Aging - metabolism
Aging - physiology
Animals
Antioxidants - metabolism
Body Temperature - physiology
Body Temperature Regulation - physiology
Carbon Dioxide - metabolism
Enzymes - metabolism
Male
Mice
Mice, Inbred C57BL
Oxygen - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The distribution type and correlative links between physiological and biochemical indices characterizing functional condition of the systems of gaseous exchange (V(O2) and V(CO2)), thermoregulation (body temperature and coefficient of thermoconductivity) and antioxidant defense have been studied in 62 young (3-5 mo.) and 58 old (23-26 mo.) male C57Bl/ 6 mice. The coefficients of variation differed significantly depending on the variable but not the age-group. Mean values of V(O2) and V(CO2), body temperature and thermoconductivity, but not activities of the antioxidant enzymes, declined in aging. Moreover, the activities of catalase, glutathione-peroxidase and glutathionereductase, i.e. enzymes involved in regulation of hydrogen peroxide level, increased in aging. The correlations between V(O2) and V(CO2), V(O2) and body temperature or V(O2) and the liver pH, as well as between the antioxidant enzyme activities exhibited little age-changes. However, three-dimensional non-linear models revealed significant age-changes in relations between the studied variables.
ISSN:2522-9028