Selective hydrolysis of nucleotides to nucleosides and free bases

The kinetics of the hydrolysis of 2′-deoxyadenosine-5′-monophosphoric acid (dAMP), 2′-deoxycytidine-5′-monophosphoric acid (dCMP), 2′-deoxyguanosine-5′-monophosphoric acid (dGMP) and tymidine-5′-monophosphoric acid (dTMP) was studied in the presence of Xanthomonas maltophilia [1]. The reaction produ...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 1999-09, Vol.54 (9), p.611-614
Main Authors: Chmielowiec, Urszula, Kruszewska, Hanna, Cybulski, Jacek
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Escherichia coli
Fundamental and applied biological sciences. Psychology
Hydrolysis
Lactobacillus acidophilus
Methods. Procedures. Technologies
Nucleosides - metabolism
Nucleotides
Nucleotides - metabolism
Pseudomonas putida
Selective hydrolysis
Xanthomonas - metabolism
Xanthomonas maltophilia
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Summary:The kinetics of the hydrolysis of 2′-deoxyadenosine-5′-monophosphoric acid (dAMP), 2′-deoxycytidine-5′-monophosphoric acid (dCMP), 2′-deoxyguanosine-5′-monophosphoric acid (dGMP) and tymidine-5′-monophosphoric acid (dTMP) was studied in the presence of Xanthomonas maltophilia [1]. The reaction products are nucleosides: 2′-deoxyadenosine (dA), 2′-deoxycytidine (dC), 2′-deoxyguanosine (dG) and tymidine (dT), respectively, or the respective free bases. Hydrolysis of dTMP and dGMP proceeded stepwise according to the sequence: nucleotide→nucleoside→free base, whereas no accumulation of the free base was observed during the hydrolysis of dAMP and dCMP.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(99)00071-3