Reactive oxygen species and redox-signaling during adaptation to changes of oxygen level

Review of last 15 years literature and own experimental data on role of reactive oxygen species (ROS) and redox signalization in induction of cell protective systems and development of adaptive resistance. Modem ideas of ROS involvement in redox signalization, induction of transcription factors and...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2008, Vol.54 (2), p.18-32
Main Authors: Sazontova, T G, Anchishkina, N A, Zhukova, A G, Bedareva, I V, Pylaeva, E A, Kriventsova, N A, Polianskaia, A A, Iurasov, A R, Arkhipenko, Iu V
Format: Article
Language:Russian
Subjects:
Adaptation, Physiological
Animals
Humans
Hypoxia - enzymology
Hypoxia - metabolism
Hypoxia - physiopathology
Muscle, Skeletal - metabolism
Myocardium - metabolism
Oxidation-Reduction
Oxygen - metabolism
Reactive Oxygen Species - metabolism
Signal Transduction
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Summary:Review of last 15 years literature and own experimental data on role of reactive oxygen species (ROS) and redox signalization in induction of cell protective systems and development of adaptive resistance. Modem ideas of ROS involvement in redox signalization, induction of transcription factors and protective proteins, ways of cell response to ROS, essential limitations of exogenic antioxidants are shown. Concept of ROS involvement in non-specific component of increase resistance is introduced. Peculiarities of author's method of adaptation to change oxygen level are discussed. Experimental data on efficacy of adaptation to periodic hypoxiahyperoxia from ROS-induced stresses are presented.
ISSN:2522-9028