A Lexicon for Homeodomain-DNA Recognition

Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work ( Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in...

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Bibliographic Details
Published in:Cell 2008-06, Vol.133 (7), p.1133-1135
Main Authors: Affolter, Markus, Slattery, Matthew, Mann, Richard S.
Format: Article
Language:English
Subjects:
Animals
DNA - chemistry
DNA - metabolism
Drosophila
Drosophila melanogaster
Homeodomain Proteins - chemistry
Homeodomain Proteins - metabolism
Mice
Protein Binding
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Summary:Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work ( Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2008.06.008