Desorption Ionization of Biomolecules on Metals

Direct desorption ionization of various types of biomolecules on metal substrates without the need of matrices was observed by a time-of-flight mass spectrometer. It provides a new convenient method for detection of small biomolecules without the confusion of ion peaks from matrix compounds. Simple...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2008-07, Vol.80 (13), p.5203-5210
Main Authors: Hsu, Nien-Yeen, Tseng, Susan Yu, Wu, Chung-Yi, Ren, Chien-Tai, Lee, Yuan-Chang, Wong, Chi-Huey, Chen, Chung-Hsuan
Format: Article
Language:English
Subjects:
Aluminum - chemistry
Aluminum Oxide - chemistry
Analytical chemistry
Chemistry
Desorption
Exact sciences and technology
Fatty Acids - chemistry
Ions
Lasers, Solid-State
Mass spectrometry
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Metals
Molecules
Oligonucleotides - chemistry
Peptides - chemistry
Polysaccharides - chemistry
Silicon
Spectrometric and optical methods
Substrates
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Summary:Direct desorption ionization of various types of biomolecules on metal substrates without the need of matrices was observed by a time-of-flight mass spectrometer. It provides a new convenient method for detection of small biomolecules without the confusion of ion peaks from matrix compounds. Simple commercial Al foil can be used as the substrate to obtain mass spectra of biomolecules without the need of an etching process to produce a porous surface such as with direct ionization on silicon (DIOS). The desorption and ionization mechanism is also discussed.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac800435r