Diurnal Amplitudes of Arterial Pressure and Heart Rate Are Dampened in Clock Mutant Mice and Adrenalectomized Mice

Arterial pressure (AP), heart rate (HR), and cardiovascular diseases, including ischemic heart attack and cerebrovascular accident, show diurnal variation. Evidence that circadian-related genes contribute to cardiovascular control has been accumulated. In this study, we measured the AP and HR of Clo...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2008-07, Vol.149 (7), p.3576-3580
Main Authors: Sei, Hiroyoshi, Oishi, Katsutaka, Chikahisa, Sachiko, Kitaoka, Kazuyoshi, Takeda, Eiji, Ishida, Norio
Format: Article
Language:English
Subjects:
Adrenal glands
Adrenalectomy
Adrenalectomy - methods
Aldosterone
Amplitudes
Animals
Biological and medical sciences
Blood pressure
Blood Pressure - physiology
Cardiovascular diseases
Cardiovascular system
Chronobiology
Circadian Rhythm - physiology
Circadian rhythms
Clock gene
CLOCK Proteins
Diurnal variations
Female
Fundamental and applied biological sciences. Psychology
Genes
Genotype
Heart diseases
Heart rate
Heart Rate - physiology
Ischemia
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Mutant Strains
Mutants
Mutation
Myocardial infarction
Stroke
Trans-Activators - genetics
Trans-Activators - physiology
Vascular diseases
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:Arterial pressure (AP), heart rate (HR), and cardiovascular diseases, including ischemic heart attack and cerebrovascular accident, show diurnal variation. Evidence that circadian-related genes contribute to cardiovascular control has been accumulated. In this study, we measured the AP and HR of Clock mutant mice on the Jcl/ICR background to determine the role of the Clock gene in cardiovascular function. Mice with mutated Clock genes had a dampened diurnal rhythm of AP and HR, compared with wild-type control mice, and this difference disappeared after adrenalectomy. The diurnal acrophase in both mean arterial pressure and HR was delayed significantly in Clock mutant mice, compared with wild-type mice, and this difference remained after adrenalectomy. Clock mutant mice had a lower concentration of plasma aldosterone, compared with wild-type mice. Our data suggest that the adrenal gland is involved in the diurnal amplitude, but not the acrophase, of AP and HR, and that the function of the Clock gene may be related to the nondipping type of AP elevation.
ISSN:0013-7227
1945-7170
DOI:10.1210/en.2007-1714